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Association details:
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Title:

23 High Tumour Pd-L1 Predicts Early Resistance to First Generation EGFR TKIs in EGFR-Mutant Lung Cancer

Published date:
08/06/2020
Excerpt:
Patients with Stage IIIB/IV lung adenocarcinoma harboring a sensitizing EGFR mutation and treated with first‐line, first or second‐generation TKI...69% received erlotinib...Compared to patients with PD‐L1 low/negative tumours those with high PD‐L1 (n = 9; 13%) had significantly shorter PFS...OS (10.8 vs 25.8 months, HR 0.22 95% CI 0.09‐0.58, P = .001).
DOI:
https://doi.org/10.1111/ajco.13417