A 62-year-old, non-smoking female with adenocarcinoma of the right lung...Her tumor cells had increased EGFR/HER1 copy number, as assessed by FISH...patient was treated with afatinib (50 mg/day). Within 2 weeks, the cervical soft-tissue swelling decreased with marked improvement in her general condition (ECOG PS: 1). On Day 15, a metabolic response was observed in a PET-CT scan.