^
Association details:
| Biomarker: | EGFR amplification |
|---|---|
| Cancer: | Esophageal Squamous Cell Carcinoma |
| Drug: | divarasib (RG6330) (KRAS G12C inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Discovery and Characterization of the Potent, Allosteric SHP2 inhibitor GDC-1971 for the Treatment of RTK/RAS Driven Tumors
Published date:
03/09/2022
Excerpt:
GDC-1971 inhibits the growth of RTK and KRAS mutant tumor models in vivo...KYSE520, an EGFR-amplified esophageal squamous cell carcinoma...NCI-H358, KRAS G12C mutant Non-Small Cell Carcinoma.
