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DRUG:

sirexatamab (DKN-01)

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Company:

BeiGene, Eli Lilly, Leap Therap

Drug class:

DKK1 protein inhibitor

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DKK1 overexpression	Gastroesophageal Junction Adenocarcinoma	DKK1 overexpression	Gastroesophageal Junction Adenocarcinoma	DKN-01 Sensitive: B - Late Trials DKN-01 Sensitive : B	DKN-01 Sensitive: B - Late Trials DKN-01 Sensitive : B
DKK1 overexpression	Gastric Cancer	DKK1 overexpression	Gastric Cancer	DKN-01 Sensitive: B - Late Trials DKN-01 Sensitive : B	DKN-01 Sensitive: B - Late Trials DKN-01 Sensitive : B
DKK1 overexpression	Gastroesophageal Junction Adenocarcinoma	DKK1 overexpression	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + DKN-01 Sensitive: C3 – Early Trials pembrolizumab + DKN-01 Sensitive : C3	pembrolizumab + DKN-01 Sensitive: C3 – Early Trials pembrolizumab + DKN-01 Sensitive : C3
DKK1 overexpression	Esophageal Squamous Cell Carcinoma	DKK1 overexpression	Esophageal Squamous Cell Carcinoma	pembrolizumab + DKN-01 Sensitive: C3 – Early Trials pembrolizumab + DKN-01 Sensitive : C3	pembrolizumab + DKN-01 Sensitive: C3 – Early Trials pembrolizumab + DKN-01 Sensitive : C3
DKK1 overexpression	Esophageal Adenocarcinoma	DKK1 overexpression	Esophageal Adenocarcinoma	pembrolizumab + DKN-01 Sensitive: C3 – Early Trials pembrolizumab + DKN-01 Sensitive : C3	pembrolizumab + DKN-01 Sensitive: C3 – Early Trials pembrolizumab + DKN-01 Sensitive : C3
DKK1 overexpression	Gastric Cancer	DKK1 overexpression	Gastric Cancer	pembrolizumab + DKN-01 Sensitive: C3 – Early Trials pembrolizumab + DKN-01 Sensitive : C3	pembrolizumab + DKN-01 Sensitive: C3 – Early Trials pembrolizumab + DKN-01 Sensitive : C3
DKK1 overexpression	Endometrial Cancer	DKK1 overexpression	Endometrial Cancer	DKN-01 Sensitive: C3 – Early Trials DKN-01 Sensitive : C3	DKN-01 Sensitive: C3 – Early Trials DKN-01 Sensitive : C3
DKK1 overexpression	Esophageal Squamous Cell Carcinoma	DKK1 overexpression	Esophageal Squamous Cell Carcinoma	DKN-01 Sensitive: C3 – Early Trials DKN-01 Sensitive : C3	DKN-01 Sensitive: C3 – Early Trials DKN-01 Sensitive : C3
DKK1 overexpression	Esophageal Adenocarcinoma	DKK1 overexpression	Esophageal Adenocarcinoma	DKN-01 Sensitive: C3 – Early Trials DKN-01 Sensitive : C3	DKN-01 Sensitive: C3 – Early Trials DKN-01 Sensitive : C3
DKK1 overexpression	Gastroesophageal Junction Adenocarcinoma	DKK1 overexpression	Gastroesophageal Junction Adenocarcinoma	tislelizumab + DKN-01 Sensitive: C3 – Early Trials tislelizumab + DKN-01 Sensitive : C3	tislelizumab + DKN-01 Sensitive: C3 – Early Trials tislelizumab + DKN-01 Sensitive : C3
DKK1 overexpression	Ovarian Cancer	DKK1 overexpression	Ovarian Cancer	DKN-01 Sensitive: C3 – Early Trials DKN-01 Sensitive : C3	DKN-01 Sensitive: C3 – Early Trials DKN-01 Sensitive : C3
PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	tislelizumab + DKN-01 Sensitive: C3 – Early Trials tislelizumab + DKN-01 Sensitive : C3	tislelizumab + DKN-01 Sensitive: C3 – Early Trials tislelizumab + DKN-01 Sensitive : C3