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GENE:

CRBN (Cereblon)

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Entrez ID:

CRBN expression	Multiple Myeloma	CRBN expression	Multiple Myeloma	lenalidomide Sensitive: C2 – Inclusion Criteria lenalidomide Sensitive : C2	lenalidomide Sensitive: C2 – Inclusion Criteria lenalidomide Sensitive : C2
CRBN underexpression	Multiple Myeloma	CRBN underexpression	Multiple Myeloma	CC-220 Sensitive: C3 – Early Trials CC-220 Sensitive : C3	CC-220 Sensitive: C3 – Early Trials CC-220 Sensitive : C3
CRBN overexpression	Multiple Myeloma	CRBN overexpression	Multiple Myeloma	thalidomide Resistant: C3 – Early Trials thalidomide Resistant : C3	thalidomide Resistant: C3 – Early Trials thalidomide Resistant : C3
CRBN overexpression	Multiple Myeloma	CRBN overexpression	Multiple Myeloma	lenalidomide Resistant: C3 – Early Trials lenalidomide Resistant : C3	lenalidomide Resistant: C3 – Early Trials lenalidomide Resistant : C3
CRBN underexpression	Multiple Myeloma	CRBN underexpression	Multiple Myeloma	lenalidomide Resistant: C3 – Early Trials lenalidomide Resistant : C3	lenalidomide Resistant: C3 – Early Trials lenalidomide Resistant : C3
CRBN underexpression	Multiple Myeloma	CRBN underexpression	Multiple Myeloma	pomalidomide Resistant: C3 – Early Trials pomalidomide Resistant : C3	pomalidomide Resistant: C3 – Early Trials pomalidomide Resistant : C3
CRBN expression	Multiple Myeloma	CRBN expression	Multiple Myeloma	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3
CRBN rs1705814T > C	Multiple Myeloma	CRBN rs1705814T > C	Multiple Myeloma	lenalidomide Sensitive: C3 – Early Trials lenalidomide Sensitive : C3	lenalidomide Sensitive: C3 – Early Trials lenalidomide Sensitive : C3
CRBN rs1714327G > C	Multiple Myeloma	CRBN rs1714327G > C	Multiple Myeloma	lenalidomide Sensitive: C3 – Early Trials lenalidomide Sensitive : C3	lenalidomide Sensitive: C3 – Early Trials lenalidomide Sensitive : C3
CRBN elevation + SPARC-L	Multiple Myeloma	CRBN elevation + SPARC-L	Multiple Myeloma	lenalidomide + azacitidine + dexamethasone Resistant: C3 – Early Trials lenalidomide + azacitidine + dexamethasone Resistant : C3	lenalidomide + azacitidine + dexamethasone Resistant: C3 – Early Trials lenalidomide + azacitidine + dexamethasone Resistant : C3
CRBN R283K	Multiple Myeloma	CRBN R283K	Multiple Myeloma	lenalidomide Resistant: C4 – Case Studies lenalidomide Resistant : C4	lenalidomide Resistant: C4 – Case Studies lenalidomide Resistant : C4
CRBN Q99	Multiple Myeloma	CRBN Q99	Multiple Myeloma	lenalidomide Resistant: C4 – Case Studies lenalidomide Resistant : C4	lenalidomide Resistant: C4 – Case Studies lenalidomide Resistant : C4