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Association details:
| Biomarker: | CRBN overexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | lenalidomide (TNFα inhibitor, IL-6 inhibitor, IL-12 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
EXPRESSION SIGNIFICANCE OF CRL4-CRBN PROTEINS COMPLEX IN MULTIPLE MYELOMA PATIENTS TREATED WITH IMMUNOMODULATORY DRUGS.
Published date:
05/14/2020
Excerpt:
The high expression of CRBN and DDB1 was significantly associated with elevated beta-2-microglobulin level (p=0.041 and p=0.013, respectively). The patients with high CRBN expression also had the higher level of monoclonal protein (p=0.004), the lower haemoglobin concentration (p=0.035) and poorer response to IMiDs treatment (p=0.034)...
