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Association details:
| Biomarker: | CLTC-ALK fusion |
|---|---|
| Cancer: | Diffuse Large B Cell Lymphoma |
| Drug: | arsenic trioxide (Apoptosis stimulant) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Arsenic trioxide inhibits anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma through targeting ALK-fusion oncoprotein
Published date:
06/13/2021
Excerpt:
As2O3 exerted anti-proliferative and pro-apoptotic activities in CLTC-ALK-positive DLBCL….mice xenografted with LM1 line were treated with vehicle (control) or As2O3 at 5 mg/kg/day for 3 weeks, a dose regimen that has been reported for xenograft mouse model of APL....As2O3 treatment significantly suppressed tumour growth...
DOI:
https://doi.org/10.1111/bjh.17581
