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BIOMARKER:

BRCA1 mutation + BRCA2 mutation + TMB-H

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Entrez ID:

Related biomarkers:

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MSI-H/dMMR + TMB-H (8)

TMB-H + PD-L1 overexpression (7)

HRD + BRCA1 mutation (7)

HRD + BRCA2 mutation (7)

MSI-H/dMMR + TMB-L (5)

BRCA1 mutation + TMB-H (3)

KMT2D mutation + TMB-H (3)

MLL3 mutation + TMB-H (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

PD-L1 expression + TMB-H (3)

BRCA1 mutation + HR positive (3)

BRCA2 mutation + HR positive (3)

HR positive + BRCA2 mutation (3)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)

HER-2 expression + TMB-H (2)

LRP1B mutation + TMB-H (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

NCOR2-NTRK1 fusion + TMB-H (2)

PAPPA2 mutation + TMB-H (2)

PD-L1 expression + TMB-H + FANCA deletion (2)

STK11 mutation + TMB-H (2)

TMB-H + EGFR exon 19 deletion (2)

TMB-H + EGFR mutation (2)

TMB-H + HER-2 positive (2)

TMB-H + PD-L1 negative (2)

TMB-H + PD-L1 underexpression (2)

TMB-H + PIK3CA mutation (2)

TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)

TMB-L + PD-L1 expression (2)

BRCA1 2080delA + CCNE1 overexpression (2)

BRCA1 mutation + HER-2 negative (2)

HR negative + BRCA1 mutation (2)

HR positive + BRCA1 mutation (2)

BRCA2 mutation + HER-2 negative (2)

HR negative + BRCA2 mutation (2)

AHNAK2 mutation + TMB-H (1)

ALK mutation + TMB-H (1)

ARID1A mutation + TMB-H (1)

ARID1B mutation + TMB-H (1)

ASPSCR1-TFE3 fusion +TMB-H (1)

BAP1 deletion + TMB-L + PD-L1 expression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-L (1)

CD20 positive + TMB-L (1)

CD74-ROS1 fusion + TMB-H (1)

CDKN2A mutation + TMB-H (1)

EGFR L858R + TMB-H (1)

EGFR T790M + TMB-H (1)

EGFR mutation + ALK negative + TMB-H (1)

ELF3 mutation + TMB-L + MSI-L/dMMR (1)

EML4-ALK fusion + TMB-L (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ERBB3 R135C + TMB-H (1)

HER-2 elevation + TMB-H (1)

HER-2 elevation + TMB-L (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HER-2 mutation + TMB-H (1)

HLA-E overexpression + TMB-L (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High IFNG gene signature + TMB-H (1)

IDH1 mutation + TMB-L (1)

IDH2 mutation + TMB-L (1)

KEAP1 mutation + TMB-H + PD-L1 overexpression (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)

KMT2C mutation + TMB-H (1)

KRAS A146 + TMB-H (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

MAP2K1 mutation + TMB-H (1)

MAP2K2 mutation + TMB-H (1)

MET mutation + TMB-H (1)

MGA mutation + TMB-L (1)

MGAM mutation + TMB-H (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSI-H/dMMR + TMB-H + POLE mutation (1)

NCR3LG1 underexpression + TMB-L (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

NPAP1 mutation + TMB-H (1)

NTRK3 mutation + TMB-H (1)

PBRM1 mutation + TMB-H (1)

PBRM1 mutation + TMB-L + MSI-L/dMMR (1)

PD-L1 amplification + PD-L2 amplification + TMB-H (1)

PD-L1 negative + TMB-L (1)

PD-L1 negative + TMB-L + STING overexpression (1)

PD-L1 overexpression + TMB-H (1)

PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)

PD-L1 overexpression + TMB-L (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

POLE E790Q + ERBB2 amplification + TMB-H (1)

POLE P286R + TMB-H (1)

POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)

POLE mutation + PD-L1 negative + TMB-H (1)

PTCH1 1504-1G>T + TMB-H (1)

PTPN11 mutation + TMB-H (1)

PTPRD mutation + TMB-H (1)

RECQL5 mutation + TMB-H (1)

RET amplification + TMB-H + PD-L1 expression (1)

RYR1 mutation + TMB-H (1)

SMARCA4 mutation + TMB-H (1)

SMARCB1 mutation + TMB-H (1)

STK11 deletion + TMB-H (1)

STK11 mutation + TMB-H + PD-L1 overexpression (1)

TMB-H + ALK rearrangement (1)

TMB-H + CDKN2B mutation (1)

TMB-H + DDR (1)

TMB-H + KDM6A mutation (1)

TMB-H + LDH elevation (1)

TMB-H + MLL2 mutation (1)

TMB-H + MSH6 F1088fs (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

TMB-H + RB1 mutation + PD-L1 underexpression (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMB-H + TERT promoter mutation (1)

TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)

TMB-L + LDH elevation (1)

TMB-L + PD-L1 underexpression (1)

TMB-L + RB1 mutation (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TPR mutation + TMB-H (1)

TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)

XIRP2 mutation + TMB-H (1)

ZNF479 mutation + TMB-H (1)

BAP1 negative + BRCA1 mutation (1)

BRCA1 hypermethylation (1)

BRCA1 mutation + AKR1C3 overexpression (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

BRCA1 mutation + PD-L1 expression (1)

BRCA1 mutation + RAD51B deletion (1)

BRCA1 mutation + RB1 deletion (1)

BRCA1 promoter methylation (1)

EGFR mutation + BRCA1 overexpression (1)

EGFR mutation + BRCA1 underexpression (1)

HR positive + BRCA1 mutation + PALB2 mutation (1)

PTEN deletion + BRCA1 mutation (1)

ALK rearrangement + BRCA2 F2801fs (1)

BRCA2 deletion + ATM mutation (1)

BRCA2 mutation + AKR1C3 overexpression (1)

BRCA2 mutation + ER positive (1)

BRCA2 mutation + ER positive + PGR positive (1)

BRCA2 mutation + RB1 deletion (1)

HR positive + BRCA2 mutation + PALB2 mutation (1)

HR positive + HER-2 negative + TMB-L (0)

NOTCH4 mutation + PD-L1 expression + TMB-H (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

ER positive + BRCA1 mutation (0)

ER positive + BRCA2 mutation (0)

MSI-H/dMMR + TMB-H (8)

TMB-H + PD-L1 overexpression (7)

HRD + BRCA1 mutation (7)

HRD + BRCA2 mutation (7)

MSI-H/dMMR + TMB-L (5)

BRCA1 mutation + TMB-H (3)

KMT2D mutation + TMB-H (3)

MLL3 mutation + TMB-H (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

PD-L1 expression + TMB-H (3)

BRCA1 mutation + HR positive (3)

BRCA2 mutation + HR positive (3)

HR positive + BRCA2 mutation (3)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)

HER-2 expression + TMB-H (2)

LRP1B mutation + TMB-H (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

NCOR2-NTRK1 fusion + TMB-H (2)

PAPPA2 mutation + TMB-H (2)

PD-L1 expression + TMB-H + FANCA deletion (2)

STK11 mutation + TMB-H (2)

TMB-H + EGFR exon 19 deletion (2)

TMB-H + EGFR mutation (2)

TMB-H + HER-2 positive (2)

TMB-H + PD-L1 negative (2)

TMB-H + PD-L1 underexpression (2)

TMB-H + PIK3CA mutation (2)

TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)

TMB-L + PD-L1 expression (2)

BRCA1 2080delA + CCNE1 overexpression (2)

BRCA1 mutation + HER-2 negative (2)

HR negative + BRCA1 mutation (2)

HR positive + BRCA1 mutation (2)

BRCA2 mutation + HER-2 negative (2)

HR negative + BRCA2 mutation (2)

AHNAK2 mutation + TMB-H (1)

ALK mutation + TMB-H (1)

ARID1A mutation + TMB-H (1)

ARID1B mutation + TMB-H (1)

ASPSCR1-TFE3 fusion +TMB-H (1)

BAP1 deletion + TMB-L + PD-L1 expression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRCA2 mutation + TMB-H (1)

BRCA2 mutation + TMB-L (1)

CD20 positive + TMB-L (1)

CD74-ROS1 fusion + TMB-H (1)

CDKN2A mutation + TMB-H (1)

EGFR L858R + TMB-H (1)

EGFR T790M + TMB-H (1)

EGFR mutation + ALK negative + TMB-H (1)

ELF3 mutation + TMB-L + MSI-L/dMMR (1)

EML4-ALK fusion + TMB-L (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

ERBB3 R135C + TMB-H (1)

HER-2 elevation + TMB-H (1)

HER-2 elevation + TMB-L (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HER-2 mutation + TMB-H (1)

HLA-E overexpression + TMB-L (1)

HR positive + TMB-H (1)

HR positive + TMB-L (1)

High IFNG gene signature + TMB-H (1)

IDH1 mutation + TMB-L (1)

IDH2 mutation + TMB-L (1)

KEAP1 mutation + TMB-H + PD-L1 overexpression (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)

KMT2C mutation + TMB-H (1)

KRAS A146 + TMB-H (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

MAP2K1 mutation + TMB-H (1)

MAP2K2 mutation + TMB-H (1)

MET mutation + TMB-H (1)

MGA mutation + TMB-L (1)

MGAM mutation + TMB-H (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSI-H/dMMR + TMB-H + POLE mutation (1)

NCR3LG1 underexpression + TMB-L (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

NPAP1 mutation + TMB-H (1)

NTRK3 mutation + TMB-H (1)

PBRM1 mutation + TMB-H (1)

PBRM1 mutation + TMB-L + MSI-L/dMMR (1)

PD-L1 amplification + PD-L2 amplification + TMB-H (1)

PD-L1 negative + TMB-L (1)

PD-L1 negative + TMB-L + STING overexpression (1)

PD-L1 overexpression + TMB-H (1)

PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)

PD-L1 overexpression + TMB-L (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

POLE E790Q + ERBB2 amplification + TMB-H (1)

POLE P286R + TMB-H (1)

POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)

POLE mutation + PD-L1 negative + TMB-H (1)

PTCH1 1504-1G>T + TMB-H (1)

PTPN11 mutation + TMB-H (1)

PTPRD mutation + TMB-H (1)

RECQL5 mutation + TMB-H (1)

RET amplification + TMB-H + PD-L1 expression (1)

RYR1 mutation + TMB-H (1)

SMARCA4 mutation + TMB-H (1)

SMARCB1 mutation + TMB-H (1)

STK11 deletion + TMB-H (1)

STK11 mutation + TMB-H + PD-L1 overexpression (1)

TMB-H + ALK rearrangement (1)

TMB-H + CDKN2B mutation (1)

TMB-H + DDR (1)

TMB-H + KDM6A mutation (1)

TMB-H + LDH elevation (1)

TMB-H + MLL2 mutation (1)

TMB-H + MSH6 F1088fs (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

TMB-H + RB1 mutation + PD-L1 underexpression (1)

TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)

TMB-H + TERT promoter mutation (1)

TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)

TMB-L + LDH elevation (1)

TMB-L + PD-L1 underexpression (1)

TMB-L + RB1 mutation (1)

TP53 S12F + KRAS G12D + TMB-L (1)

TP53 mutation + FANCM mutation + TMB-H (1)

TP53 mutation + LRP1B mutation + TMB-H (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TPR mutation + TMB-H (1)

TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)

XIRP2 mutation + TMB-H (1)

ZNF479 mutation + TMB-H (1)

BAP1 negative + BRCA1 mutation (1)

BRCA1 hypermethylation (1)

BRCA1 mutation + AKR1C3 overexpression (1)

BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)

BRCA1 mutation + PD-L1 expression (1)

BRCA1 mutation + RAD51B deletion (1)

BRCA1 mutation + RB1 deletion (1)

BRCA1 promoter methylation (1)

EGFR mutation + BRCA1 overexpression (1)

EGFR mutation + BRCA1 underexpression (1)

HR positive + BRCA1 mutation + PALB2 mutation (1)

PTEN deletion + BRCA1 mutation (1)

ALK rearrangement + BRCA2 F2801fs (1)

BRCA2 deletion + ATM mutation (1)

BRCA2 mutation + AKR1C3 overexpression (1)

BRCA2 mutation + ER positive (1)

BRCA2 mutation + ER positive + PGR positive (1)

BRCA2 mutation + RB1 deletion (1)

HR positive + BRCA2 mutation + PALB2 mutation (1)

HR positive + HER-2 negative + TMB-L (0)

NOTCH4 mutation + PD-L1 expression + TMB-H (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

ER positive + BRCA1 mutation (0)

ER positive + BRCA2 mutation (0)

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BRCA1 mutation + BRCA2 mutation + TMB-H

Non Small Cell Lung Cancer

Resistant: C3 – Early Trials

Resistant: C3 – Early Trials