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BIOMARKER:
BRAF D594G
i
Other names:
BRAF (B-raf proto-oncogene)
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News alerts, weekly reports and conference planners
Entrez ID:
673
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
HER-2 amplification + RAS wild-type + BRAF wild-type (9)
BRAF V600K + LDH elevation (3)
BRAF V600E + MSI-H (2)
BRAF V600E + PD-L1 expression (2)
BRAF V600E + PD-L1 expression (2)
BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)
BRAF V600E + ROS1 fusion (2)
BRAF mutation + MET amplification (2)
BRAF mutation + MSI-L/dMMR (2)
BRAF mutation + TERT overexpression (2)
BRAF wild-type + HER-2 positive (2)
EZR overexpression + BRAF V600E (2)
IDH1 mutation + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
IDH2 mutation + BRAF V600E (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
MSI-H/dMMR + BRAF V600E (2)
PD-L1 expression + NRAS Q61R + BRAF D594N (2)
PD-L1 overexpression + BRAF V600E (2)
RAS wild-type + BRAF wild-type + HER-2 positive (2)
ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)
ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)
BRAF E501Q + PD-L1 negative (1)
BRAF V600 + LDH elevation (1)
BRAF V600 + LDH elevation + PD-L1 negative (1)
BRAF V600E + CDKN2A deletion + MYCN amplification (1)
BRAF V600E + CDKN2A deletion + RB1 expression (1)
BRAF V600E + EGFR expression (1)
BRAF V600E + PTEN deletion (1)
BRAF V600E + SOX2 amplification (1)
BRAF V600K + CDKN2A deletion + RB1 expression (1)
BRAF mutation + PD-L1 overexpression (1)
BRAF mutation + TMB-H (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)
BRAF wild-type + HGF elevation (1)
CD8 elevation + BRAF V600 (1)
Chr t(11;14) + BRAF mutation (1)
EGFR exon 19 deletion + BRAF G464A (1)
EGFR overexpression + BRAF V600E (1)
EGFR overexpression + BRAF mutation (1)
HER-2 amplification + BRAF wild-type (1)
HR positive + BRAF V600E (1)
KIAA1549-BRAF fusion + MET amplification (1)
KIAA1549-BRAF fusion + PTEN deletion (1)
KRAS wild-type + BRAF V600E (1)
LDH elevation + BRAF mutation (1)
MAP2K1 mutation + BRAF wild-type (1)
MSI-H/dMMR + BRAF Mutation (1)
MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)
NRAS mutation + BRAF wild-type (1)
PD-L1 expression + BRAF negative (1)
PIK3CA mutation + BRAF wild-type (1)
SEMA6A overexpression + BRAF mutation (1)
SRC overexpression + BRAF V600E (1)
TNFAIP3 overexpression + BRAF mutation (1)
PD-L1 overexpression + BRAF mutation (0)
HER-2 amplification + RAS wild-type + BRAF wild-type (9)
BRAF V600K + LDH elevation (3)
BRAF V600E + MSI-H (2)
BRAF V600E + PD-L1 expression (2)
BRAF V600E + PD-L1 expression (2)
BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)
BRAF V600E + ROS1 fusion (2)
BRAF mutation + MET amplification (2)
BRAF mutation + MSI-L/dMMR (2)
BRAF mutation + TERT overexpression (2)
BRAF wild-type + HER-2 positive (2)
EZR overexpression + BRAF V600E (2)
IDH1 mutation + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
IDH2 mutation + BRAF V600E (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
MSI-H/dMMR + BRAF V600E (2)
PD-L1 expression + NRAS Q61R + BRAF D594N (2)
PD-L1 overexpression + BRAF V600E (2)
RAS wild-type + BRAF wild-type + HER-2 positive (2)
ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)
ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)
BRAF E501Q + PD-L1 negative (1)
BRAF V600 + LDH elevation (1)
BRAF V600 + LDH elevation + PD-L1 negative (1)
BRAF V600E + CDKN2A deletion + MYCN amplification (1)
BRAF V600E + CDKN2A deletion + RB1 expression (1)
BRAF V600E + EGFR expression (1)
BRAF V600E + PTEN deletion (1)
BRAF V600E + SOX2 amplification (1)
BRAF V600K + CDKN2A deletion + RB1 expression (1)
BRAF mutation + PD-L1 overexpression (1)
BRAF mutation + TMB-H (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)
BRAF wild-type + HGF elevation (1)
CD8 elevation + BRAF V600 (1)
Chr t(11;14) + BRAF mutation (1)
EGFR exon 19 deletion + BRAF G464A (1)
EGFR overexpression + BRAF V600E (1)
EGFR overexpression + BRAF mutation (1)
HER-2 amplification + BRAF wild-type (1)
HR positive + BRAF V600E (1)
KIAA1549-BRAF fusion + MET amplification (1)
KIAA1549-BRAF fusion + PTEN deletion (1)
KRAS wild-type + BRAF V600E (1)
LDH elevation + BRAF mutation (1)
MAP2K1 mutation + BRAF wild-type (1)
MSI-H/dMMR + BRAF Mutation (1)
MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)
NRAS mutation + BRAF wild-type (1)
PD-L1 expression + BRAF negative (1)
PIK3CA mutation + BRAF wild-type (1)
SEMA6A overexpression + BRAF mutation (1)
SRC overexpression + BRAF V600E (1)
TNFAIP3 overexpression + BRAF mutation (1)
PD-L1 overexpression + BRAF mutation (0)
›
Associations
News
Trials
VERI cancer hierarchy
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BRAF D594G
Non Small Cell Lung Cancer
BRAF D594G
Non Small Cell Lung Cancer
trametinib
Resistant: C3 – Early Trials
trametinib
Resistant
:
C3
trametinib
Resistant: C3 – Early Trials
trametinib
Resistant
:
C3
BRAF D594G
Non Small Cell Lung Cancer
BRAF D594G
Non Small Cell Lung Cancer
trametinib + dabrafenib
Resistant: C3 – Early Trials
trametinib + dabrafenib
Resistant
:
C3
trametinib + dabrafenib
Resistant: C3 – Early Trials
trametinib + dabrafenib
Resistant
:
C3
BRAF D594G
Ampulla of Vater Carcinoma
BRAF D594G
Ampulla of Vater Carcinoma
binimetinib + encorafenib
Sensitive: C3 – Early Trials
binimetinib + encorafenib
Sensitive
:
C3
binimetinib + encorafenib
Sensitive: C3 – Early Trials
binimetinib + encorafenib
Sensitive
:
C3
BRAF D594G
Melanoma
BRAF D594G
Melanoma
BVD-523
Sensitive: C3 – Early Trials
BVD-523
Sensitive
:
C3
BVD-523
Sensitive: C3 – Early Trials
BVD-523
Sensitive
:
C3
BRAF D594G
Colorectal Cancer
BRAF D594G
Colorectal Cancer
cetuximab + encorafenib + BVD-523
Sensitive: C3 – Early Trials
cetuximab + encorafenib + BVD-523
Sensitive
:
C3
cetuximab + encorafenib + BVD-523
Sensitive: C3 – Early Trials
cetuximab + encorafenib + BVD-523
Sensitive
:
C3
BRAF D594G
Cholangiocarcinoma
BRAF D594G
Cholangiocarcinoma
trametinib
Sensitive: C4 – Case Studies
trametinib
Sensitive
:
C4
trametinib
Sensitive: C4 – Case Studies
trametinib
Sensitive
:
C4
^
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