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GENE:

BMI1 (BMI1 proto-oncogene, polycomb ring finger)

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BMI1 overexpression	Glioblastoma	BMI1 overexpression	Glioblastoma	PTC-209 Sensitive: D – Preclinical PTC-209 Sensitive : D	PTC-209 Sensitive: D – Preclinical PTC-209 Sensitive : D
BMI1 expression	Multiple Myeloma	BMI1 expression	Multiple Myeloma	venetoclax Sensitive: D – Preclinical venetoclax Sensitive : D	venetoclax Sensitive: D – Preclinical venetoclax Sensitive : D
CD34 positive + BMI1 overexpression + MAP2K1 elevation	Acute Myelogenous Leukemia	CD34 positive + BMI1 overexpression + MAP2K1 elevation	Acute Myelogenous Leukemia	trametinib + BMIi-1 Sensitive: D – Preclinical trametinib + BMIi-1 Sensitive : D	trametinib + BMIi-1 Sensitive: D – Preclinical trametinib + BMIi-1 Sensitive : D