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    Association details:
    Biomarker:BMI1 overexpression
    Cancer:Glioblastoma
    Drug:PTC-209 (BMI1 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Cell Cycle
    Title:

    Targeting of BMI-1 with PTC-209 inhibits glioblastoma development

    Excerpt:
    As desribed previously [27], U87MG-luciferase cells (5 × 105) were injected intracerebrally. One week after transplantion, the nude mice were treated with PTC-209...The bioluminescence imaging showed tumor growth was significantly abrogated in the PTC-209 treatment group compared with the DMSO control group tumors.
    DOI:
    10.1080/15384101.2018.1469872