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DRUG CLASS:

BCMA inhibitor

DRUG CLASS:

BCMA inhibitor

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No biomarker	Multiple Myeloma	No biomarker	Multiple Myeloma	teclistamab-cqyv Sensitive: A1 - Approval teclistamab-cqyv Sensitive : A1	teclistamab-cqyv Sensitive: A1 - Approval teclistamab-cqyv Sensitive : A1
No biomarker	Multiple Myeloma	No biomarker	Multiple Myeloma	elranatamab-bcmm Sensitive: A1 - Approval elranatamab-bcmm Sensitive : A1	elranatamab-bcmm Sensitive: A1 - Approval elranatamab-bcmm Sensitive : A1
No biomarker	Multiple Myeloma	No biomarker	Multiple Myeloma	MK-4002 Sensitive: B - Late Trials MK-4002 Sensitive : B	MK-4002 Sensitive: B - Late Trials MK-4002 Sensitive : B
TNFRSF17-L	Multiple Myeloma	TNFRSF17-L	Multiple Myeloma	AMG 701 Sensitive: C3 – Early Trials AMG 701 Sensitive : C3	AMG 701 Sensitive: C3 – Early Trials AMG 701 Sensitive : C3
IL6-L	Multiple Myeloma	IL6-L	Multiple Myeloma	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3
TNFRSF17 amplification	Multiple Myeloma	TNFRSF17 amplification	Multiple Myeloma	elranatamab-bcmm Resistant: C3 – Early Trials elranatamab-bcmm Resistant : C3	elranatamab-bcmm Resistant: C3 – Early Trials elranatamab-bcmm Resistant : C3
CCL3-L	Multiple Myeloma	CCL3-L	Multiple Myeloma	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3
IL17C-L	Multiple Myeloma	IL17C-L	Multiple Myeloma	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3
Chr del(17p)	Multiple Myeloma	Chr del(17p)	Multiple Myeloma	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3
Chr t(14;16)	Multiple Myeloma	Chr t(14;16)	Multiple Myeloma	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3
Chr t(4;14)	Multiple Myeloma	Chr t(4;14)	Multiple Myeloma	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3	elranatamab-bcmm Sensitive: C3 – Early Trials elranatamab-bcmm Sensitive : C3
TNFRSF17 positive	Multiple Myeloma	TNFRSF17 positive	Multiple Myeloma	teclistamab-cqyv Sensitive: D – Preclinical teclistamab-cqyv Sensitive : D	teclistamab-cqyv Sensitive: D – Preclinical teclistamab-cqyv Sensitive : D
TNFRSF17 underexpression	Multiple Myeloma	TNFRSF17 underexpression	Multiple Myeloma	CTX-8573 Sensitive: D – Preclinical CTX-8573 Sensitive : D	CTX-8573 Sensitive: D – Preclinical CTX-8573 Sensitive : D
TNFRSF17 expression	Multiple Myeloma	TNFRSF17 expression	Multiple Myeloma	CC-93269 + CC-220 Sensitive: D – Preclinical CC-93269 + CC-220 Sensitive : D	CC-93269 + CC-220 Sensitive: D – Preclinical CC-93269 + CC-220 Sensitive : D
TNFRSF17 expression	Multiple Myeloma	TNFRSF17 expression	Multiple Myeloma	CC-93269 + CC-92480 Sensitive: D – Preclinical CC-93269 + CC-92480 Sensitive : D	CC-93269 + CC-92480 Sensitive: D – Preclinical CC-93269 + CC-92480 Sensitive : D
GPRC5D expression	Multiple Myeloma	GPRC5D expression	Multiple Myeloma	JNJ-5322 Sensitive: D – Preclinical JNJ-5322 Sensitive : D	JNJ-5322 Sensitive: D – Preclinical JNJ-5322 Sensitive : D
TNFRSF17 expression	Multiple Myeloma	TNFRSF17 expression	Multiple Myeloma	JNJ-5322 Sensitive: D – Preclinical JNJ-5322 Sensitive : D	JNJ-5322 Sensitive: D – Preclinical JNJ-5322 Sensitive : D
TNFRSF17 expression + GPRC5D expression	Multiple Myeloma	TNFRSF17 expression + GPRC5D expression	Multiple Myeloma	JNJ-5322 Sensitive: D – Preclinical JNJ-5322 Sensitive : D	JNJ-5322 Sensitive: D – Preclinical JNJ-5322 Sensitive : D