^
Association details:
| Biomarker: | BCL2 overexpression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | IACS-010759 (Electron transport complex I inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Inhibiting Mitochondria Function By Bcl-2 Inhibitor Venetoclax and Complex I Inhibitor Iacs-010759 Eliminate Leukemia Cells in Pre-Clinical AML Models
Published date:
11/06/2019
Excerpt:
Further, cells with BCL-2 overexpression were less sensitive to IACS-010759.
DOI:
https://doi.org/10.1182/blood-2019-124494
