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    Association details:
    Biomarker:BAP1 mutation
    Cancer:Uveal Melanoma
    Drug:quisinostat (JNJ 26481585) (HDAC inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Mol Cancer Res
    Title:

    Dual screen for efficacy and toxicity identifies HDAC inhibitor with distinctive activity spectrum for BAP1-mutant uveal melanoma

    Published date:
    10/19/2020
    Excerpt:
    Quisinostat was further validated in a mouse model and found to prevent the growth of BAP1-mutant uveal melanomas.
    DOI:
    10.1158/1541-7786.MCR-20-0434