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Association details:
| Biomarker: | BAP1 mutation |
|---|---|
| Cancer: | Uveal Melanoma |
| Drug: | quisinostat (JNJ 26481585) (HDAC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Dual screen for efficacy and toxicity identifies HDAC inhibitor with distinctive activity spectrum for BAP1-mutant uveal melanoma
Published date:
10/19/2020
Excerpt:
Quisinostat was further validated in a mouse model and found to prevent the growth of BAP1-mutant uveal melanomas.
DOI:
10.1158/1541-7786.MCR-20-0434
