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BIOMARKER:

BAP1 mutation

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Other names: BAP1, BRCA1 Associated Protein 1, BRCA1 Associated Protein-1 (Ubiquitin Carboxy-Terminal Hydrolase), Ubiquitin Carboxyl-Terminal Hydrolase BAP1, Cerebral Protein 6, Ubiquitin Carboxy-Terminal Hydrolase, BRCA1-Associated Protein 1, Cerebral Protein-13, HUCEP-13, KIAA0272, Hucep-6, UCHL2
Entrez ID:
Related biomarkers:
BAP1 mutation
Mesothelioma
tazemetostat
Sensitive: C2 – Inclusion Criteria
BAP1 mutation
Urothelial Cancer
olaparib
Sensitive: C2 – Inclusion Criteria
BAP1 mutation
Melanoma
vorinostat
Sensitive: C2 – Inclusion Criteria
BAP1 mutation
Mesothelioma
olaparib
Resistant: C2 – Inclusion Criteria
BAP1 mutation
Cholangiocarcinoma
cisplatin + gemcitabine
Resistant: C3 – Early Trials
BAP1 mutation
RCC
everolimus
Resistant: C3 – Early Trials
BAP1 mutation
RCC
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
BAP1 mutation
Mesothelioma
rucaparib
Sensitive: C3 – Early Trials
BAP1 mutation
RCC
Glutamate inhibitor
Sensitive: D – Preclinical
BAP1 mutation
Uveal Melanoma
JNJ 26481585
Sensitive: D – Preclinical