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BIOMARKER:
ALK rearrangement + TP53 mutation
i
Other names:
Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor, TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1
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Entrez ID:
238
;
7157
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
TP53 deletion (21)
ALK amplification (3)
LPL deletion + TP53 deletion (1)
TP53 amplification (1)
TP53 deletion (21)
ALK amplification (3)
LPL deletion + TP53 deletion (1)
TP53 amplification (1)
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ALK rearrangement + TP53 mutation
Non Small Cell Lung Cancer
ALK rearrangement + TP53 mutation
Non Small Cell Lung Cancer
alectinib
Resistant: C3 – Early Trials
alectinib
Resistant
:
C3
alectinib
Resistant: C3 – Early Trials
alectinib
Resistant
:
C3
ALK rearrangement + TP53 mutation
Non Small Cell Lung Cancer
ALK rearrangement + TP53 mutation
Non Small Cell Lung Cancer
crizotinib
Resistant: C3 – Early Trials
crizotinib
Resistant
:
C3
crizotinib
Resistant: C3 – Early Trials
crizotinib
Resistant
:
C3
ALK rearrangement + TP53 mutation
Non Small Cell Lung Cancer
ALK rearrangement + TP53 mutation
Non Small Cell Lung Cancer
ALK inhibitor
Resistant: C3 – Early Trials
ALK inhibitor
Resistant
:
C3
ALK inhibitor
Resistant: C3 – Early Trials
ALK inhibitor
Resistant
:
C3
ALK rearrangement + TP53 mutation
Non Small Cell Lung Cancer
ALK rearrangement + TP53 mutation
Non Small Cell Lung Cancer
alectinib + ixazomib
Sensitive: D – Preclinical
alectinib + ixazomib
Sensitive
:
D
alectinib + ixazomib
Sensitive: D – Preclinical
alectinib + ixazomib
Sensitive
:
D
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