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Association details:
| Biomarker: | ALK positive |
|---|---|
| Cancer: | Neuroblastoma |
| Drug Class: | CAR-T immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Generation of ALK CAR-T Cells for Neuroblastoma Therapy
Published date:
05/28/2021
Excerpt:
To specifically target NB cells, we developed a series of ALK chimeric antigen receptor (CAR) T constructs from antibodies that recognize both human and mouse ALK....Murine ALK CAR-T cells are able to control the growth of ALK+...NB in syngeneic tumor models without detectable toxicity.
