^
Association details:
| Biomarker: | ALK F1174L |
|---|---|
| Cancer: | Neuroblastoma |
| Drug: | TAE-684 (ALK inhibitor, LRRK2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Excerpt:
...dose-dependent growth inhibition of the SH-SY5Y (F1174L)...neuroblastoma cell lines with increasing concentrations of TAE684...These results are in agreement with data from a recent study showing sensitivity of these cell lines to TAE684...
DOI:
10.1038/nature07397
