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    Association details:
    Biomarker:ALK F1174L
    Cancer:Neuroblastoma
    Drug:Xalkori (crizotinib) (ALK inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Sci Transl Med
    Title:

    Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma

    Excerpt:
    ...ability of crizotinib to inhibit proliferation of neuroblastoma cell lines and xenografts expressing mutated or wild-type ALK...cell lines harboring F1174L-mutated ALK were relatively resistant to crizotinib…
    DOI:
    10.1126/scitranslmed.3002950