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Association details:
| Biomarker: | ALK F1174L |
|---|---|
| Cancer: | Neuroblastoma |
| Drug: | AZD3463 (ALK inhibitor, IGF-1R inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis
Excerpt:
...ALK inhibitor AZD3463 can significantly suppress the viability of ALK WT and mutant NB cell lines and lead to tumor cell death in a dose-and time-dependent manners…Fig 1B…
DOI:
10.1038/srep19423
