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GENE:

ABCB1 (ATP Binding Cassette Subfamily B Member 1)

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Tempus xT Assay (1)

Tempus xT Assay (1)

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ABCB1 mutation + VEGFA mutation	Mantle Cell Lymphoma	ABCB1 mutation + VEGFA mutation	Mantle Cell Lymphoma	lenalidomide Sensitive: B - Late Trials lenalidomide Sensitive : B	lenalidomide Sensitive: B - Late Trials lenalidomide Sensitive : B
ABCB1 2677G>T/W	Mantle Cell Lymphoma	ABCB1 2677G>T/W	Mantle Cell Lymphoma	lenalidomide Sensitive: B - Late Trials lenalidomide Sensitive : B	lenalidomide Sensitive: B - Late Trials lenalidomide Sensitive : B
ABCB1 C3435T	HER2 Positive Breast Cancer	ABCB1 C3435T	HER2 Positive Breast Cancer	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3
ABCB1 C1236T	HER2 Positive Breast Cancer	ABCB1 C1236T	HER2 Positive Breast Cancer	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3
ABCB1 G2677T	HER2 Positive Breast Cancer	ABCB1 G2677T	HER2 Positive Breast Cancer	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3
ABCB1 G1236T + ABCB1 G2677T	HER2 Positive Breast Cancer	ABCB1 G1236T + ABCB1 G2677T	HER2 Positive Breast Cancer	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3
ABCB1 overexpression	Squamous Cell Carcinoma of Head and Neck	ABCB1 overexpression	Squamous Cell Carcinoma of Head and Neck	cisplatin + 5-fluorouracil Sensitive: C3 – Early Trials cisplatin + 5-fluorouracil Sensitive : C3	cisplatin + 5-fluorouracil Sensitive: C3 – Early Trials cisplatin + 5-fluorouracil Sensitive : C3
ABCB1 3435C>T	B Acute Lymphoblastic Leukemia	ABCB1 3435C>T	B Acute Lymphoblastic Leukemia	imatinib Sensitive: C3 – Early Trials imatinib Sensitive : C3	imatinib Sensitive: C3 – Early Trials imatinib Sensitive : C3
ABCB1 3435C>T	Chronic Myeloid Leukemia	ABCB1 3435C>T	Chronic Myeloid Leukemia	imatinib Sensitive: C3 – Early Trials imatinib Sensitive : C3	imatinib Sensitive: C3 – Early Trials imatinib Sensitive : C3
ABCB1 overexpression	Head and Neck Cancer	ABCB1 overexpression	Head and Neck Cancer	paclitaxel Resistant: C3 – Early Trials paclitaxel Resistant : C3	paclitaxel Resistant: C3 – Early Trials paclitaxel Resistant : C3
ABCB1 G412G	Anaplastic Astrocytoma	ABCB1 G412G	Anaplastic Astrocytoma	temozolomide Sensitive: C3 – Early Trials temozolomide Sensitive : C3	temozolomide Sensitive: C3 – Early Trials temozolomide Sensitive : C3
ABCB1 G412G	Glioblastoma	ABCB1 G412G	Glioblastoma	temozolomide Sensitive: C3 – Early Trials temozolomide Sensitive : C3	temozolomide Sensitive: C3 – Early Trials temozolomide Sensitive : C3