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Association details:
| Biomarker: | ABCB1 G1236T + ABCB1 G2677T |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug: | Herceptin (trastuzumab) (HER2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapy
Published date:
08/16/2012
Excerpt:
PFS was significantly longer in ABCB1 1236CC and/or 2677TT carriers compared to the others (p = 0.006)...Our data support that ABCB1 polymorphisms may predict PFS after first-line TH chemotherapy in patients with HER2-positive MBC.
Secondary therapy:
Chemotherapy
DOI:
10.1159/000341359
