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BIOMARKER:
MLL rearrangement
i
Other names:
HTRX1, HTRX, MLL1A, Mixed Lineage Leukemia 1, Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 1, CXXC7, MLL1, TRX1, Zinc Finger Protein HRX, Trithorax-Like Protein, ALL-1, Lysine (K)-Specific Methyltransferase 2A, CXXC-Type Zinc Finger Protein 7, Histone-Lysine N-Methyltransferase 2A, Myeloid/Lymphoid Or Mixed-Lineage Leukemia, Lysine Methyltransferase 2A, MLL, Myeloid/Lymphoid Or Mixed-Lineage Leukemia, KMT2A
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News alerts, weekly reports and conference planners
Associations
(10)
News
Trials
Search handles
@Anand_88_Patel
@DrHKantarjian
@drsangeetmd
@hemedoc
Search handles
@Anand_88_Patel
@DrHKantarjian
@drsangeetmd
@hemedoc
Filter by
Latest
over1year
Activity of menin inhibitor ziftomenib (KO-539) as monotherapy or in combinations against #AML cells with MLL1 rearrangement or mutant NPM1 https://t.co/bCIgUycpt8 via @LeukemiaJnl #leusm @MDAndersonNews @Daver_Leukemia @DrKTakahashi (@DrHKantarjian)
over 1 year ago
NPM1 (Nucleophosmin 1)
|
NPM1 mutation • MLL rearrangement • MLL rearrangement
|
ziftomenib (KO-539)
almost2years
Day 7: @BloodAdvances therapy-related ALL article by @CanerSaygin et al! #leusm -median OS 27 months -higher rates of KMT2A (MLL) rearrangement and MDS-like karyotype abnormalities https://t.co/QyKShRkQOC (@Anand_88_Patel)
almost 2 years ago
KMT2A (Lysine Methyltransferase 2A)
|
MLL rearrangement • MLL rearrangement
almost2years
#ALFlive22 #leusm Armstrong: MLL rearrangement associated leukemias have a unique gene expression profile, linked to high level HoxA9 expr. Menin essential for transcription of subset of MLL targets. Menin inhibitor disrupts MLL and MLLr-partner mediated txn. (@hemedoc)
almost 2 years ago
KMT2A (Lysine Methyltransferase 2A) • HOXA9 (Homeobox A9)
|
MLL rearrangement • MLL rearrangement
over2years
Now we have menin inhibitors that should improve KMT2A (MLL) #leukemia outcome Outcomes of Acute Lymphoblastic Leukemia with KMT2A (MLL) rearrangement - The MD Anderson Experience @MDAndersonNews https://t.co/hCgNGL0lhO via @BloodAdvances | #leusm #ALL (@DrHKantarjian)
over 2 years ago
KMT2A (Lysine Methyltransferase 2A)
|
MLL rearrangement • MLL rearrangement
over2years
Outcomes of ALL with KMT2A (MLL) rearrangement - The MD Anderson Experience.https://t.co/WuZyC8gtgp @grichardmd @DrHKantarjian Dr.Jabbour @MDAndersonNews KMT2A rearrangements are ☠️in myeloid or lymphoid acute leuks #leusm @BloodAdvances (@drsangeetmd)
over 2 years ago
KMT2A (Lysine Methyltransferase 2A)
|
KMT2A rearrangement • MLL rearrangement • MLL rearrangement
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