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BIOMARKER:
KRAS G12A
i
Other names:
KRAS, KRAS1, KRAS2, Kirsten rat sarcoma viral oncogene homolog
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Entrez ID:
3845
Related biomarkers:
Expression
Mutation
CNA
Others
‹
STK11 deletion + KRAS mutation (6)
KRAS G12C + PD-L1 overexpression (4)
KRAS mutation + PD-L1 expression (4)
CPS1 overexpression + KRAS mutation + STK11 mutation (3)
HER-2 amplification + KRAS G12D (3)
KEAP1 deletion + KRAS mutation (3)
PD-L1 overexpression + KRAS mutation (3)
EGFR exon 19 deletion + KRAS mutation (2)
KRAS G12C + PD-L1 underexpression (2)
KRAS mutation + PD-L1 negative (2)
MSI-L/dMMR + KRAS G12V (2)
AXL overexpression + KRAS G12C (1)
CDH2 overexpression + KRAS wild-type (1)
Chr t(11;14) + KRAS mutation (1)
EGFR C797S + KRAS amplification + RB1 deletion (1)
EGFR L858R + KRAS amplification + RB1 deletion (1)
EGFR T790M + KRAS amplification + RB1 deletion (1)
EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR expression + KRAS G12C (1)
EGFR overexpression + KRAS 13D (1)
EGFR overexpression + KRAS mutation (1)
FGFR1 overexpression + KRAS G12C (1)
GNA13 deletion + KRAS mutation (1)
GOPC-ROS1 fusion + KRAS Q61H (1)
HER-2 amplification + KRAS exon 2 wild-type (1)
HER-2 amplification + KRAS wild-type (1)
HER-2 overexpression + KRAS wild-type (1)
IGF1R overexpression + KRAS mutation (1)
IR overexpression + KRAS mutation (1)
IRS2 amplification + KRAS mutation (1)
KEAP1 mutation + KRAS wild-type (1)
KRAS A146 + TMB-H (1)
KRAS G12C + PD-L1 expression (1)
KRAS G12C + PD-L1 underexpression + STK11 mutation (1)
KRAS G12D + Chr del(9)(p21) (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
KRAS G12D + TP53 deletion (1)
KRAS amplification + BRAF wild-type (1)
KRAS amplification + RAS wild-type (1)
KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)
KRAS mutation + BCL2A1 overexpression (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + EGFR amplification (1)
KRAS mutation + ER expression (1)
KRAS mutation + HER-2 positive (1)
KRAS mutation + HR positive (1)
KRAS mutation + PD-L1 underexpression (1)
KRAS mutation + PIK3CA wild-type (1)
KRAS mutation + PTPN11 overexpression (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
KRAS mutation + YKL-40 overexpression (1)
KRAS wild-type + BRAF V600E (1)
KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)
KRAS mutation + STK11 mutation + AXL expression (1)
MLL-AFF1 fusion + KRAS mutation (1)
MSI-H/dMMR + KRAS G12D (1)
MSI-H/dMMR + KRAS Mutation (1)
MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)
MTAP deletion + KRAS G12C (1)
PD-L1 negative + KRAS G12C (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
POMK-NRG1 fusion + KRAS mutation (1)
POMK‐NRG1 fusion + KRAS G12D (1)
PTEN deletion + KRAS G12C (1)
RET positive + KRAS G12V (1)
ROS1 fusion + KRAS G12C (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
STRN-ALK fusion + KRAS G13D (1)
TP53 S12F + KRAS G12D + TMB-L (1)
HER-2 amplification + KRAS G12C (0)
PRMT5 overexpression + KRAS mutation (0)
STK11 deletion + KRAS mutation (6)
KRAS G12C + PD-L1 overexpression (4)
KRAS mutation + PD-L1 expression (4)
CPS1 overexpression + KRAS mutation + STK11 mutation (3)
HER-2 amplification + KRAS G12D (3)
KEAP1 deletion + KRAS mutation (3)
PD-L1 overexpression + KRAS mutation (3)
EGFR exon 19 deletion + KRAS mutation (2)
KRAS G12C + PD-L1 underexpression (2)
KRAS mutation + PD-L1 negative (2)
MSI-L/dMMR + KRAS G12V (2)
AXL overexpression + KRAS G12C (1)
CDH2 overexpression + KRAS wild-type (1)
Chr t(11;14) + KRAS mutation (1)
EGFR C797S + KRAS amplification + RB1 deletion (1)
EGFR L858R + KRAS amplification + RB1 deletion (1)
EGFR T790M + KRAS amplification + RB1 deletion (1)
EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)
EGFR expression + KRAS G12C (1)
EGFR overexpression + KRAS 13D (1)
EGFR overexpression + KRAS mutation (1)
FGFR1 overexpression + KRAS G12C (1)
GNA13 deletion + KRAS mutation (1)
GOPC-ROS1 fusion + KRAS Q61H (1)
HER-2 amplification + KRAS exon 2 wild-type (1)
HER-2 amplification + KRAS wild-type (1)
HER-2 overexpression + KRAS wild-type (1)
IGF1R overexpression + KRAS mutation (1)
IR overexpression + KRAS mutation (1)
IRS2 amplification + KRAS mutation (1)
KEAP1 mutation + KRAS wild-type (1)
KRAS A146 + TMB-H (1)
KRAS G12C + PD-L1 expression (1)
KRAS G12C + PD-L1 underexpression + STK11 mutation (1)
KRAS G12D + Chr del(9)(p21) (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
KRAS G12D + TP53 deletion (1)
KRAS amplification + BRAF wild-type (1)
KRAS amplification + RAS wild-type (1)
KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)
KRAS mutation + BCL2A1 overexpression (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + EGFR amplification (1)
KRAS mutation + ER expression (1)
KRAS mutation + HER-2 positive (1)
KRAS mutation + HR positive (1)
KRAS mutation + PD-L1 underexpression (1)
KRAS mutation + PIK3CA wild-type (1)
KRAS mutation + PTPN11 overexpression (1)
KRAS mutation + TP53 mutation + GNA13 deletion (1)
KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)
KRAS mutation + YKL-40 overexpression (1)
KRAS wild-type + BRAF V600E (1)
KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)
KRAS mutation + STK11 mutation + AXL expression (1)
MLL-AFF1 fusion + KRAS mutation (1)
MSI-H/dMMR + KRAS G12D (1)
MSI-H/dMMR + KRAS Mutation (1)
MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)
MTAP deletion + KRAS G12C (1)
PD-L1 negative + KRAS G12C (1)
PD-L1 overexpression + KRAS G12C + TP53 mutation (1)
POMK-NRG1 fusion + KRAS mutation (1)
POMK‐NRG1 fusion + KRAS G12D (1)
PTEN deletion + KRAS G12C (1)
RET positive + KRAS G12V (1)
ROS1 fusion + KRAS G12C (1)
STK11 mutation + KRAS mutation + TP53 deletion (1)
STRN-ALK fusion + KRAS G13D (1)
TP53 S12F + KRAS G12D + TMB-L (1)
HER-2 amplification + KRAS G12C (0)
PRMT5 overexpression + KRAS mutation (0)
›
Related tests:
therascreen® KRAS RGQ PCR Kit (5)
therascreen® KRAS RGQ PCR Kit (5)
Associations
(14)
News
Trials
Search handles
@HHorinouchi
@StephenVLiu
@cczielinski
@pashtoonkasi
Search handles
@HHorinouchi
@StephenVLiu
@cczielinski
@pashtoonkasi
Filter by
Latest
11ms
BI-2493 / BI-2865: non-covalent inhibitors, binding the inactive state of KRAS, blocked the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. @Boehringer #LCSM https://t.co/7m549MX20c (@HHorinouchi)
11 months ago
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS wild-type • RAS wild-type • KRAS G12A • KRAS G12 • KRAS G13 • KRAS Q61H • KRAS A146V • KRAS G13C
|
BI-2493
12ms
The Frequency of Specific #KRAS Mutations, and Their Impact on Treatment Choice and Survival, in Patients With Metastatic Colorectal Cancer. 🇪🇸 🇪🇺 G12A incidence, though! @manjuggm @fireflyann @afm1003 @udai_banerji https://t.co/WE7F1kImFv (@CrozrX)
12 months ago
Clinical • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12A
1year
A 12-11 One more trial!! Pan #RAS G12i Ph I/Ib 📌https://t.co/xNGnaEYbli 📌n=141 📌RMC6326 📌For KRAS G12A/G12D/ G12R/ G12S or G12V mutant #CRC & other solid tumors 📌Primary end points: DLT, Safety 📌Trial open in the US https://t.co/2y2vpJDmAH #CRCTrialsChat #CRCSM (@manjuggm)
1 year ago
Clinical
|
KRAS (KRAS proto-oncogene GTPase) • RAS (Rat Sarcoma Virus)
|
KRAS G12D • KRAS G12V • KRAS G12A • KRAS G12 • KRAS G12S
2years
Any ideas what to offer to a patient with NSCLC with KRAS G12A mutation which has progressed on all kinds of immune and chemotherapy? (@cczielinski)
2 years ago
Clinical
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12A • KRAS G12
2years
#TTLC22 P14 by Dr. @JessBoyceMD characterizes patients with NSCLC and soft tissue metastases (skin, muscle). Majority had #KRAS mutations (esp G12A) and that has definitely been my own experience. Curious about what is driving the tropism here. (@StephenVLiu)
2 years ago
Clinical
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12A • KRAS G12
almost3years
As you can see in this #ovariancancer #LGSOC presentation, response across multiple #KRAS variants and WT, among them G12A top right corner. Not aware of that specific mutation response in other cancers for this comprehensive #MAPK #FAKi #KRAS platform. (@CrozrX)
almost 3 years ago
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12A • KRAS G12
3years
🙌🏾 to open at @IntMedatIowa few days. While #pancreascancer #PANCSM is the major cohort, the vaccine 💉 is for multiple KRAS mutations. So #lcsm #HPBCSM #cholangiocarcinoma #CRCSM and I believe #ovariancancer. Using the #ctDNA @NateraOncology. G12D G12R G12V G12A G12C G12S G13D (@pashtoonkasi)
3 years ago
Circulating tumor DNA
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12D • KRAS G12V • KRAS G12A • KRAS G12S
over3years
#KRAS #lungcancer variants G12V G12D G12A WT @IASLC @LungCancerEu @GO2Foundation @ALKLungCancer @lcrf_org @LUNGevity Dr. Ross Camidge discusses launch of #RAMP202 Vs-6766 /Defactinib registrational clinical study (RAF/MEKi -FAKi) @dave6408 @SarahCannonDocs https://t.co/U33fPMonYL (@CrozrX)
over 3 years ago
Clinical
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS G12D • KRAS G12V • KRAS G12A • KRAS G12
|
avutometinib (VS-6766) • defactinib (VS-6063)
over3years
I'll dare to put in little diversity in here! ☺#wizard @udai_banerji accomplishment in a fantastic RAF •MEKi efficacy, DOR and safety profile in KRAS •G12V •G12D •G12A •WT variants! Amazing breakthrough in #LGSOC #NSCLC #PancreaticCancer #CRC #LessIsMore #IntermittentDosing (@CrozrX)
over 3 years ago
Clinical
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS G12D • KRAS G12V • KRAS G12A • KRAS G12
over3years
Promising multiple KRAS variants platform in dual RAF •MEK inhibitor VS-6766 (RO5126766) FAKi •Defactinib. G12V G12D G12A WT, giant leap in KRAS development! Efficacy, durability, safety profile! @udai_banerji is a wizard! @JackWestMD #NSCLC #PDAC #CRC #LGSOC (@CrozrX)
over 3 years ago
Clinical
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS G12D • KRAS G12V • KRAS G12A • KRAS G12
|
avutometinib (VS-6766) • defactinib (VS-6063)
over3years
Not just G12C, but G12V •G12D •WT •G12A KRAS variants #NSCLC #LGSOC #PancreaticCancer #PDAC #CRC Vs-6766 /Defactinib https://t.co/KpdKLDWdLq (@CrozrX)
over 3 years ago
KRAS (KRAS proto-oncogene GTPase)
|
KRAS G12D • KRAS G12V • KRAS G12A • KRAS G12
|
avutometinib (VS-6766) • defactinib (VS-6063)
over3years
It's not only G12C with KRAS breakthrough data, but also G12D G12V G12A WT.. which bears major implications for pancreatic cancer, CRC, MM.. Also, synergistic combo with AMG510 in KRAS G12C. Phenomenal 65% ORR, 4% TEAE! Expanding cohorts.. https://t.co/VDN8PpGNsm (@CrozrX)
over 3 years ago
KRAS (KRAS proto-oncogene GTPase)
|
KRAS G12C • KRAS G12D • KRAS G12V • KRAS G12A • KRAS G12
|
Lumakras (sotorasib)
over3years
65% ORR, 4% TEAE across G12D G12V WT G12A.. KRAS variants. LGSOC cohort expansion to pancreatic cancer, CRC, NSCLC. Also great synergy with AMG510 KRAS G12C. https://t.co/VDN8PpYoQW (@CrozrX)
over 3 years ago
KRAS (KRAS proto-oncogene GTPase)
|
KRAS G12C • KRAS G12D • KRAS G12V • KRAS G12A • KRAS G12
|
Lumakras (sotorasib)
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