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BIOMARKER:

PD-L1 expression

i
Entrez ID:
Related biomarkers:
Related tests:
Phase N/A
Ballad Health
Recruiting
Last update posted :
02/28/2025
Initiation :
02/11/2025
Primary completion :
03/01/2026
Completion :
03/01/2027
PD-L1
|
PD-L1 expression
Phase 1/2
National Cancer Institute (NCI)
Suspended
Last update posted :
02/24/2025
Initiation :
02/27/2025
Primary completion :
12/30/2033
Completion :
12/30/2035
PD-L1
|
PD-L1 expression
|
Anktiva (nogapendekin alfa inbakicept-pmln) • H1299 lung cancer cell lysate vaccine with Montanide ISA-51 VG adjuvant
Phase 3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
01/19/2018
Primary completion :
06/01/2027
Completion :
06/01/2027
PD-L1 • MSI • MLH1 • MSH6 • MSH2
|
PD-L1 expression • BRAF V600E • MSI-H/dMMR
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • 5-fluorouracil • oxaliplatin • Aybintio (bevacizumab biosimilar) • leucovorin calcium • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • Zirabev (bevacizumab-bvzr) • Krabeva (bevacizumab biosimilar) • fluorouracil topical • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Vasforda (bevacizumab biosimilar)
Phase 1
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
07/07/2022
Primary completion :
09/01/2025
Completion :
09/01/2025
PD-L1 • FGFR2 • NECTIN4
|
PD-L1 expression
|
Balversa (erdafitinib) • Padcev (enfortumab vedotin-ejfv)
Phase 3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
06/16/2020
Primary completion :
12/15/2025
Completion :
12/15/2025
EGFR • PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • cisplatin • carboplatin • gemcitabine • paclitaxel • pemetrexed • Pembroria (pembrolizumab biosimilar) • liposomal gemcitabine (FF-10832)
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/24/2025
Initiation :
02/06/2017
Primary completion :
04/14/2023
Completion :
05/15/2026
TMB • CD8 • CD4
|
PD-L1 expression
|
Keytruda (pembrolizumab) • Pembroria (pembrolizumab biosimilar)
Phase 2
BeiGene
Completed
Last update posted :
02/24/2025
Initiation :
08/20/2021
Primary completion :
02/01/2024
Completion :
02/01/2024
PD-L1
|
PD-L1 expression
|
Tevimbra (tislelizumab-jsgr) • Avzivi (bevacizumab-tnjn) • ociperlimab (BGB-A1217)
Phase 1/2
Sarcoma Oncology Research Center, LLC
Recruiting
Last update posted :
02/24/2025
Initiation :
04/13/2017
Primary completion :
12/31/2030
Completion :
07/31/2031
PD-L1 • PD-1
|
PD-L1 expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Yondelis (trabectedin)
Phase 2/3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
03/13/2023
Primary completion :
12/15/2027
Completion :
12/15/2027
PD-L1
|
PD-L1 expression
|
Avastin (bevacizumab) • Erbitux (cetuximab) • cisplatin • Tecentriq (atezolizumab) • carboplatin • docetaxel • Aybintio (bevacizumab biosimilar) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn)
Phase 2
Medical College of Wisconsin
Active, not recruiting
Last update posted :
02/24/2025
Initiation :
03/05/2020
Primary completion :
07/14/2025
Completion :
08/13/2025
HER-2 • PD-L1 • PGR • PD-L2
|
PD-L1 expression • HER-2 negative • PGR positive
|
carboplatin • albumin-bound paclitaxel • cyclophosphamide • pegylated liposomal doxorubicin • Libtayo (cemiplimab-rwlc) • cyclophosphamide intravenous • doxorubicin liposomal
Phase 2
Jonsson Comprehensive Cancer Center
Recruiting
Last update posted :
02/24/2025
Initiation :
06/30/2021
Primary completion :
01/31/2026
Completion :
01/31/2027
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab)
Phase 2
Genentech, Inc.
Recruiting
Last update posted :
02/21/2025
Initiation :
11/06/2020
Primary completion :
12/30/2025
Completion :
03/06/2029
PD-L1 • KRAS • BRAF • ALK • RET • ROS1 • NTRK1 • NTRK3 • NTRK2
|
PD-L1 expression • KRAS mutation • KRAS G12C • BRAF mutation • BRAF V600 • RET fusion • ALK fusion • RET mutation • ROS1 fusion • KRAS G12
|
Tecentriq (atezolizumab) • Zelboraf (vemurafenib) • Rozlytrek (entrectinib) • Alecensa (alectinib) • Cotellic (cobimetinib) • Gavreto (pralsetinib) • divarasib (RG6330)
Phase 2/3
Shanghai Zhongshan Hospital
Recruiting
Last update posted :
02/21/2025
Initiation :
01/20/2021
Primary completion :
12/01/2025
Completion :
12/01/2026
TMB • MSI • CEACAM5 • MUC16
|
PD-L1 expression
|
Lenvima (lenvatinib) • Loqtorzi (toripalimab-tpzi) • oxaliplatin
Phase 1
Seagen Inc.
Recruiting
Last update posted :
02/21/2025
Initiation :
10/25/2022
Primary completion :
11/18/2027
Completion :
11/17/2028
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • PF-08046054
Phase 1
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/21/2025
Initiation :
07/13/2020
Primary completion :
12/01/2027
Completion :
12/01/2027
CD4
|
PD-L1 expression
|
bintrafusp alfa (M7824) • PDS01ADC
Phase 3
Summit Therapeutics
Recruiting
Last update posted :
02/20/2025
Initiation :
10/26/2023
Primary completion :
12/31/2027
Completion :
12/31/2028
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • Yidafan (ivonescimab)
Phase N/A
UNICANCER
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
06/27/2018
Primary completion :
01/02/2024
Completion :
12/01/2025
EGFR • ALK
|
PD-L1 expression • PD-L1 overexpression • ALK negative
Phase 3
Amgen
Recruiting
Last update posted :
02/20/2025
Initiation :
11/16/2023
Primary completion :
06/30/2026
Completion :
06/30/2031
PD-L1 • KRAS
|
PD-L1 expression • PD-L1 negative
|
Keytruda (pembrolizumab) • carboplatin • Lumakras (sotorasib)
Phase 1/2
Centessa Pharmaceuticals (UK) Limited
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
03/28/2023
Primary completion :
10/01/2025
Completion :
01/05/2027
PD-L1 • MSI
|
PD-L1 expression
|
itanistomig (LB101)
Phase 1/2
Hoffmann-La Roche
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
12/27/2017
Primary completion :
09/30/2025
Completion :
11/30/2026
PD-L1
|
PD-L1 expression
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • carboplatin • gemcitabine • docetaxel • Cotellic (cobimetinib) • pemetrexed • ipatasertib (RG7440) • Trodelvy (sacituzumab govitecan-hziy) • Actemra IV (tocilizumab) • tiragolumab (RG6058) • Repatha (evolocumab) • camonsertib (RP-3500) • cibisatamab (RG7802) • ciforadenant (CPI-444) • zanzalintinib (XL092)
Phase 1
Genentech, Inc.
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
08/17/2022
Primary completion :
03/31/2026
Completion :
03/31/2026
EGFR • BRAF • ALK
|
PD-L1 expression • BRAF wild-type
|
Tecentriq (atezolizumab) • migoprotafib (RLY-1971) • omeprazole
Phase 2
Hoffmann-La Roche
Active, not recruiting
Last update posted :
02/19/2025
Initiation :
07/18/2023
Primary completion :
12/24/2026
Completion :
12/24/2026
HER-2 • PD-L1 • ER • CD4
|
PD-L1 expression
|
Keytruda (pembrolizumab) • albumin-bound paclitaxel • tobemstomig (RG6139)
Phase 3
Shanghai Junshi Bioscience Co., Ltd.
Active, not recruiting
Last update posted :
02/19/2025
Initiation :
06/29/2020
Primary completion :
05/31/2025
Completion :
09/01/2026
PD-L1 • TMB
|
PD-L1 expression
|
Lenvima (lenvatinib) • Loqtorzi (toripalimab-tpzi)
Phase 2/3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/19/2025
Initiation :
10/07/2022
Primary completion :
12/31/2027
Completion :
12/31/2027
EGFR • PD-L1 • ALK • ROS1
|
PD-L1 expression • ALK mutation
|
Keytruda (pembrolizumab) • Opdivo (nivolumab) • Yervoy (ipilimumab) • carboplatin • paclitaxel • albumin-bound paclitaxel • pemetrexed • ABP 206 (nivolumab biosimilar) • Pembroria (pembrolizumab biosimilar) • Pemfexy (pemetrexed)
Phase 2/3
Canadian Cancer Trials Group
Recruiting
Last update posted :
02/19/2025
Initiation :
05/26/2020
Primary completion :
12/31/2026
Completion :
07/30/2027
EGFR • PD-L1 • ALK
|
PD-L1 expression
|
Keytruda (pembrolizumab)
Phase 2
MedSIR
Completed
Last update posted :
02/19/2025
Initiation :
12/14/2017
Primary completion :
10/31/2018
Completion :
12/23/2020
HER-2 • PD-L1 • ER • PGR • TMB
|
PD-L1 expression • HER-2 positive • HR positive • HER-2 negative • HR positive + HER-2 negative
|
Keytruda (pembrolizumab) • Halaven (eribulin mesylate)
Phase 1
National Cancer Institute (NCI)
Not yet recruiting
Last update posted :
02/18/2025
Initiation :
02/21/2025
Primary completion :
06/01/2027
Completion :
06/01/2027
PD-L1 • CD68 • CRP
|
PD-L1 expression
|
Keytruda (pembrolizumab) • emavusertib (CA-4948)
Phase 2
Pfizer
Active, not recruiting
Last update posted :
02/18/2025
Initiation :
03/18/2020
Primary completion :
03/03/2022
Completion :
04/30/2025
EGFR • PD-L1 • BRAF • ALK • ROS1
|
PD-L1 expression • EGFR mutation • BRAF mutation • ALK translocation
|
sasanlimab (PF-06801591)
Phase 1
Sapience Therapeutics
Recruiting
Last update posted :
02/17/2025
Initiation :
06/05/2023
Primary completion :
05/31/2026
Completion :
05/31/2027
PD-L1 • MSI • BRCA
|
PD-L1 expression • MSI-H/dMMR • BRCA mutation
|
Avastin (bevacizumab) • 5-fluorouracil • irinotecan • Fruzaqla (fruquintinib) • Lonsurf (trifluridine/tipiracil) • leucovorin calcium • ST316
Phase 2
Canadian Cancer Trials Group
Completed
Last update posted :
02/17/2025
Initiation :
12/14/2016
Primary completion :
06/20/2021
Completion :
01/29/2025
PD-L1
|
PD-L1 expression
|
Imfinzi (durvalumab) • Imjudo (tremelimumab-actl)
Phase 1/2
GlaxoSmithKline
Not yet recruiting
Last update posted :
02/17/2025
Initiation :
02/28/2025
Primary completion :
12/16/2027
Completion :
06/01/2028
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • cisplatin • carboplatin • pemetrexed • Jemperli (dostarlimab-gxly)
Phase 2
M.D. Anderson Cancer Center
Recruiting
Last update posted :
02/17/2025
Initiation :
06/02/2023
Primary completion :
08/07/2025
Completion :
08/07/2027
PD-L1 • HRD • CDK12 • CHEK2 • RAD51 • RAD51B • BRIP1 • RAD51C • RAD51D • CHEK1 • RAD54L • FANCL • RAD52
|
PD-L1 expression
|
Zejula (niraparib) • Jemperli (dostarlimab-gxly)
Phase 1
Centre hospitalier de l'Université de Montréal ...
Recruiting
Last update posted :
02/14/2025
Initiation :
06/29/2022
Primary completion :
04/15/2025
Completion :
04/15/2027
PD-L1 • BRAF
|
PD-L1 expression
|
Keytruda (pembrolizumab) • Opdivo (nivolumab)
Phase 1/2
BeiGene
Completed
Last update posted :
02/14/2025
Initiation :
11/13/2018
Primary completion :
02/06/2025
Completion :
02/06/2025
PD-L1
|
PD-L1 expression
|
Tevimbra (tislelizumab-jsgr) • alcestobart (LBL-007) • surzebiclimab (BGB-A425)
Phase 3
BeiGene
Completed
Last update posted :
02/14/2025
Initiation :
12/13/2018
Primary completion :
02/28/2023
Completion :
08/27/2024
PD-L1
|
PD-L1 expression
|
cisplatin • 5-fluorouracil • Tevimbra (tislelizumab-jsgr) • capecitabine • oxaliplatin
Phase 3
Merck Sharp & Dohme LLC
Completed
Last update posted :
02/14/2025
Initiation :
03/13/2019
Primary completion :
05/19/2021
Completion :
04/24/2024
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
Phase 1
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/13/2025
Initiation :
07/22/2015
Primary completion :
09/30/2026
Completion :
09/30/2026
PD-L1
|
PD-L1 expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • CS1002 (ipilimumab biosimilar) • ABP 206 (nivolumab biosimilar) • CMAB 819 (nivolumab biosimilar)
Phase 2
Centre Hospitalier Annecy Genevois
Completed
Last update posted :
02/13/2025
Initiation :
11/06/2018
Primary completion :
10/19/2023
Completion :
10/19/2023
EGFR • PD-L1 • BRAF • ALK
|
PD-L1 expression • EGFR mutation • BRAF mutation • BRAF V600 • ALK translocation
|
Opdivo (nivolumab) • Prolia (denosumab) • zoledronic acid
Phase 2
AstraZeneca
Recruiting
Last update posted :
02/13/2025
Initiation :
04/14/2022
Primary completion :
05/09/2030
Completion :
05/09/2030
EGFR • PD-L1 • ALK
|
PD-L1 expression
|
cisplatin • carboplatin • Imfinzi (durvalumab) • paclitaxel • pemetrexed • Datroway (datopotamab deruxtecan) • oleclumab (MEDI9447) • rilvegostomig (AZD2936) • volrustomig (MEDI5752) • falbikitug (AZD0171) • monalizumab (IPH2201)
Phase 1/2
AstraZeneca
Recruiting
Last update posted :
02/13/2025
Initiation :
09/14/2021
Primary completion :
08/18/2026
Completion :
03/16/2028
PD-L1
|
PD-L1 expression
|
rilvegostomig (AZD2936)