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BIOMARKER:
PD-L1 expression
i
Other names:
PD-L1, CD274, HPD-L1, PD-L1, B7H1, PDL1, Programmed death ligand 1, B7-H1, B7-H, PDCD1L1, PDCD1LG1, PDCD1 Ligand 1, B7 homolog 1, CD274 Antigen, Programmed cell death 1 ligand 1, CD274 molecule
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Entrez ID:
29126
Related biomarkers:
Expression
Mutation
CNA
Others
‹
PD-L1 overexpression (181)
PD-L1 underexpression (46)
PD-L1 negative (28)
HER-2 negative + PD-L1 expression (12)
HER-2 positive + PD-L1 expression (3)
HR negative + PD-L1 expression (2)
MSLN overexpression + PD-L1 overexpression (2)
PD-L1 expression + CD68 positive (2)
PD-L1 expression + HER-2 overexpression (2)
PD-L1 expression + PVR expression (2)
PD-L1 overexpression + CD8 overexpression (2)
TTF1 expression + PD-L1 expression (2)
miR-625-5p underexpression + PD-L1 overexpression (2)
AXL overexpression + PD-L1 expression (1)
CGAS overexpression + PD-L1 overexpression (1)
CMTM4 expression + PD-L1 expression (1)
CMTM6 expression + PD-L1 expression (1)
CMTM6 overexpression + PD-L1 overexpression (1)
CXCL12 expression + PD-L1 underexpression (1)
HLA-A underexpression + PD-L1 expression (1)
HR positive + PD-L1 expression (1)
IGFBP2 overexpression + PD-L1 overexpression (1)
MHC-II overexpression + PD-L1 negative (1)
MHC-II overexpression + PD-L1 underexpression (1)
NKX2-1 expression + PD-L1 expression (1)
NR1H4 overexpression + PD‑L1 underexpression (1)
NT5E overexpression + PD-L1 expression (1)
PD-1 underexpression + PD-L1 overexpression (1)
PD-L1 expression + CD14 positive (1)
PD-L1 expression + CD47 expression (1)
PD-L1 expression + CD8 negative + GZMB negative (1)
PD-L1 expression + CD8 positive (1)
PD-L1 expression + CTLA4 expression (1)
PD-L1 expression + MTOR overexpression (1)
PD-L1 expression + REV3L overexpression (1)
PD-L1 overexpression + APOBEC3B overexpression (1)
PD-L1 overexpression + CCL5 overexpression (1)
PD-L1 overexpression + CD163 underexpression (1)
PD-L1 overexpression + ER positive (1)
PD-L1 overexpression + GZMA overexpression (1)
PD-L1 overexpression + LAG3 expression + CTAG1B expression (1)
PD-L1 overexpression + PD-L2 underexpression (1)
PD-L1 overexpression + SOX2 overexpression (1)
RBM17 expression + PD-L1 expression (1)
RET positive + PD-L1 overexpression (1)
SNX20 overexpression + PD-L1 overexpression (1)
STK11 underexpression + PD-L1 overexpression (1)
TFRC overexpression + PD-L1 underexpression (1)
TNFSF4 overexpression + PD-L1 overexpression (1)
TTF1 expression + PD-L1 overexpression (1)
HER-2 negative + HR negative + PD-L1 expression (0)
PD-L1 expression + HER-2 expression (0)
PD-L1 expression + LAG3 expression (0)
PD-L1 expression + TTF1 expression (0)
TMB + PD-L1 expression (0)
PD-L1 overexpression (181)
PD-L1 underexpression (46)
PD-L1 negative (28)
HER-2 negative + PD-L1 expression (12)
HER-2 positive + PD-L1 expression (3)
HR negative + PD-L1 expression (2)
MSLN overexpression + PD-L1 overexpression (2)
PD-L1 expression + CD68 positive (2)
PD-L1 expression + HER-2 overexpression (2)
PD-L1 expression + PVR expression (2)
PD-L1 overexpression + CD8 overexpression (2)
TTF1 expression + PD-L1 expression (2)
miR-625-5p underexpression + PD-L1 overexpression (2)
AXL overexpression + PD-L1 expression (1)
CGAS overexpression + PD-L1 overexpression (1)
CMTM4 expression + PD-L1 expression (1)
CMTM6 expression + PD-L1 expression (1)
CMTM6 overexpression + PD-L1 overexpression (1)
CXCL12 expression + PD-L1 underexpression (1)
HLA-A underexpression + PD-L1 expression (1)
HR positive + PD-L1 expression (1)
IGFBP2 overexpression + PD-L1 overexpression (1)
MHC-II overexpression + PD-L1 negative (1)
MHC-II overexpression + PD-L1 underexpression (1)
NKX2-1 expression + PD-L1 expression (1)
NR1H4 overexpression + PD‑L1 underexpression (1)
NT5E overexpression + PD-L1 expression (1)
PD-1 underexpression + PD-L1 overexpression (1)
PD-L1 expression + CD14 positive (1)
PD-L1 expression + CD47 expression (1)
PD-L1 expression + CD8 negative + GZMB negative (1)
PD-L1 expression + CD8 positive (1)
PD-L1 expression + CTLA4 expression (1)
PD-L1 expression + MTOR overexpression (1)
PD-L1 expression + REV3L overexpression (1)
PD-L1 overexpression + APOBEC3B overexpression (1)
PD-L1 overexpression + CCL5 overexpression (1)
PD-L1 overexpression + CD163 underexpression (1)
PD-L1 overexpression + ER positive (1)
PD-L1 overexpression + GZMA overexpression (1)
PD-L1 overexpression + LAG3 expression + CTAG1B expression (1)
PD-L1 overexpression + PD-L2 underexpression (1)
PD-L1 overexpression + SOX2 overexpression (1)
RBM17 expression + PD-L1 expression (1)
RET positive + PD-L1 overexpression (1)
SNX20 overexpression + PD-L1 overexpression (1)
STK11 underexpression + PD-L1 overexpression (1)
TFRC overexpression + PD-L1 underexpression (1)
TNFSF4 overexpression + PD-L1 overexpression (1)
TTF1 expression + PD-L1 overexpression (1)
HER-2 negative + HR negative + PD-L1 expression (0)
PD-L1 expression + HER-2 expression (0)
PD-L1 expression + LAG3 expression (0)
PD-L1 expression + TTF1 expression (0)
TMB + PD-L1 expression (0)
›
Related tests:
PD-L1 IHC 22C3 pharmDx (55)
VENTANA PD-L1 (SP263) Assay (31)
VENTANA PD-L1 (SP142) Assay (15)
PD-L1 IHC 28-8 pharmDx (4)
OncoTect iO® Lung Kit
PD-L1 IHC 22C3 pharmDx (55)
VENTANA PD-L1 (SP263) Assay (31)
VENTANA PD-L1 (SP142) Assay (15)
PD-L1 IHC 28-8 pharmDx (4)
OncoTect iO® Lung Kit
Associations
(356)
News
Trials
Phase
Status
Apply
Phase
Status
Apply
Study of Longitudinal Plasma PD-L1 Testing With Immunotherapy in Lung Cancer (NCT06849518)
Phase N/A
Ballad Health
Ballad Health
Recruiting
Phase N/A
Ballad Health
Recruiting
Last update posted :
02/28/2025
Initiation :
02/11/2025
Primary completion :
03/01/2026
Completion :
03/01/2027
PD-L1
|
PD-L1 expression
Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer (NCT05642195)
Phase 1/2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Suspended
Phase 1/2
National Cancer Institute (NCI)
Suspended
Last update posted :
02/24/2025
Initiation :
02/27/2025
Primary completion :
12/30/2033
Completion :
12/30/2035
PD-L1
|
PD-L1 expression
|
Anktiva (nogapendekin alfa inbakicept-pmln) • H1299 lung cancer cell lysate vaccine with Montanide ISA-51 VG adjuvant
Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer, the COMMIT Study (NCT02997228)
Phase 3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
01/19/2018
Primary completion :
06/01/2027
Completion :
06/01/2027
PD-L1 • MSI • MLH1 • MSH6 • MSH2
|
PD-L1 expression • BRAF V600E • MSI-H/dMMR
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • 5-fluorouracil • oxaliplatin • Aybintio (bevacizumab biosimilar) • leucovorin calcium • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • Zirabev (bevacizumab-bvzr) • Krabeva (bevacizumab biosimilar) • fluorouracil topical • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Vasforda (bevacizumab biosimilar)
Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy (NCT04963153)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 1
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
07/07/2022
Primary completion :
09/01/2025
Completion :
09/01/2025
PD-L1 • FGFR2 • NECTIN4
|
PD-L1 expression
|
Balversa (erdafitinib) • Padcev (enfortumab vedotin-ejfv)
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-Small Cell Lung Cancer, ALCHEMIST Trial (ACCIO) (NCT04267848)
Phase 3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
06/16/2020
Primary completion :
12/15/2025
Completion :
12/15/2025
EGFR • PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • cisplatin • carboplatin • gemcitabine • paclitaxel • pemetrexed • Pembroria (pembrolizumab biosimilar) • liposomal gemcitabine (FF-10832)
Pembrolizumab in Treating Patients With Desmoplastic Melanoma That Can or Cannot Be Removed by Surgery (SWOG 1512) (NCT02775851)
Phase 2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/24/2025
Initiation :
02/06/2017
Primary completion :
04/14/2023
Completion :
05/15/2026
TMB • CD8 • CD4
|
PD-L1 expression
|
Keytruda (pembrolizumab) • Pembroria (pembrolizumab biosimilar)
A Study Investigating the Efficacy and Safety of Ociperlimab and Tislelizumab and BAT1706 Combinations in Patients With Advanced HCC (AdvanTIG-206) (NCT04948697)
Phase 2
BeiGene
BeiGene
Completed
Phase 2
BeiGene
Completed
Last update posted :
02/24/2025
Initiation :
08/20/2021
Primary completion :
02/01/2024
Completion :
02/01/2024
PD-L1
|
PD-L1 expression
|
Tevimbra (tislelizumab-jsgr) • Avzivi (bevacizumab-tnjn) • ociperlimab (BGB-A1217)
SAINT:Trabectedin, Ipilimumab and Nivolumab for Previously Treated Advanced Soft Tissue Sarcoma (NCT03138161)
Phase 1/2
Sarcoma Oncology Research Center, LLC
Sarcoma Oncology Research Center, LLC
Recruiting
Phase 1/2
Sarcoma Oncology Research Center, LLC
Recruiting
Last update posted :
02/24/2025
Initiation :
04/13/2017
Primary completion :
12/31/2030
Completion :
07/31/2031
PD-L1 • PD-1
|
PD-L1 expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Yondelis (trabectedin)
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers (ECOG-ACRIN EA3202) (NCT05063552)
Phase 2/3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 2/3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
03/13/2023
Primary completion :
12/15/2027
Completion :
12/15/2027
PD-L1
|
PD-L1 expression
|
Avastin (bevacizumab) • Erbitux (cetuximab) • cisplatin • Tecentriq (atezolizumab) • carboplatin • docetaxel • Aybintio (bevacizumab biosimilar) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn)
Cemiplimab in High-risk or Locally Advanced Luminal and Triple Negative Breast Cancer (NCT04243616)
Phase 2
Medical College of Wisconsin
Medical College of Wisconsin
Active, not recruiting
Phase 2
Medical College of Wisconsin
Active, not recruiting
Last update posted :
02/24/2025
Initiation :
03/05/2020
Primary completion :
07/14/2025
Completion :
08/13/2025
HER-2 • PD-L1 • PGR • PD-L2
|
PD-L1 expression • HER-2 negative • PGR positive
|
carboplatin • albumin-bound paclitaxel • cyclophosphamide • pegylated liposomal doxorubicin • Libtayo (cemiplimab-rwlc) • cyclophosphamide intravenous • doxorubicin liposomal
Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia (NCT04712851)
Phase 2
Jonsson Comprehensive Cancer Center
Jonsson Comprehensive Cancer Center
Recruiting
Phase 2
Jonsson Comprehensive Cancer Center
Recruiting
Last update posted :
02/24/2025
Initiation :
06/30/2021
Primary completion :
01/31/2026
Completion :
01/31/2027
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab)
A Study of Multiple Therapies in Biomarker-Selected Patients With Resectable Stages IB-III Non-Small Cell Lung Cancer (NAUTIKA1) (NCT04302025)
Phase 2
Genentech, Inc.
Genentech, Inc.
Recruiting
Phase 2
Genentech, Inc.
Recruiting
Last update posted :
02/21/2025
Initiation :
11/06/2020
Primary completion :
12/30/2025
Completion :
03/06/2029
PD-L1 • KRAS • BRAF • ALK • RET • ROS1 • NTRK1 • NTRK3 • NTRK2
|
PD-L1 expression • KRAS mutation • KRAS G12C • BRAF mutation • BRAF V600 • RET fusion • ALK fusion • RET mutation • ROS1 fusion • KRAS G12
|
Tecentriq (atezolizumab) • Zelboraf (vemurafenib) • Rozlytrek (entrectinib) • Alecensa (alectinib) • Cotellic (cobimetinib) • Gavreto (pralsetinib) • divarasib (RG6330)
Phase II-III Clinical Trial of PD1 Antibody (Toripalimab), Lenvatinib and GEMOX Neoadjuvant Treatment for Resectable Intrahepatic Cholangiocarcinoma with High-risk Recurrence Factors (NCT04669496)
Phase 2/3
Shanghai Zhongshan Hospital
Shanghai Zhongshan Hospital
Recruiting
Phase 2/3
Shanghai Zhongshan Hospital
Recruiting
Last update posted :
02/21/2025
Initiation :
01/20/2021
Primary completion :
12/01/2025
Completion :
12/01/2026
TMB • MSI • CEACAM5 • MUC16
|
PD-L1 expression
|
Lenvima (lenvatinib) • Loqtorzi (toripalimab-tpzi) • oxaliplatin
A Study of SGN-PDL1V in Advanced Solid Tumors (SGNPDL1V-001) (NCT05208762)
Phase 1
Seagen Inc.
Seagen Inc.
Recruiting
Phase 1
Seagen Inc.
Recruiting
Last update posted :
02/21/2025
Initiation :
10/25/2022
Primary completion :
11/18/2027
Completion :
11/17/2028
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • PF-08046054
Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies (20-C-0012) (NCT04235777)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 1
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/21/2025
Initiation :
07/13/2020
Primary completion :
12/01/2027
Completion :
12/01/2027
CD4
|
PD-L1 expression
|
bintrafusp alfa (M7824) • PDS01ADC
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients (HARMONi-3) (NCT05899608)
Phase 3
Summit Therapeutics
Summit Therapeutics
Recruiting
Phase 3
Summit Therapeutics
Recruiting
Last update posted :
02/20/2025
Initiation :
10/26/2023
Primary completion :
12/31/2027
Completion :
12/31/2028
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • Yidafan (ivonescimab)
Identifying the Predictive Factors of Response to PD-1 or PD-L1 Antagonists (CHECK'UP) (NCT03412058)
Phase N/A
UNICANCER
UNICANCER
Active, not recruiting
Phase N/A
UNICANCER
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
06/27/2018
Primary completion :
01/02/2024
Completion :
12/01/2025
EGFR • ALK
|
PD-L1 expression • PD-L1 overexpression • ALK negative
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202) (NCT05920356)
Phase 3
Amgen
Amgen
Recruiting
Phase 3
Amgen
Recruiting
Last update posted :
02/20/2025
Initiation :
11/16/2023
Primary completion :
06/30/2026
Completion :
06/30/2031
PD-L1 • KRAS
|
PD-L1 expression • PD-L1 negative
|
Keytruda (pembrolizumab) • carboplatin • Lumakras (sotorasib)
A Study to Evaluate Safety, Tolerability and Preliminary Activity of LB101 in Participants with Advanced Solid Tumors (NCT05821777)
Phase 1/2
Centessa Pharmaceuticals (UK) Limited
Centessa Pharmaceuticals (UK) Limited
Active, not recruiting
Phase 1/2
Centessa Pharmaceuticals (UK) Limited
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
03/28/2023
Primary completion :
10/01/2025
Completion :
01/05/2027
PD-L1 • MSI
|
PD-L1 expression
|
itanistomig (LB101)
A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer) (Morpheus Lung) (NCT03337698)
Phase 1/2
Hoffmann-La Roche
Hoffmann-La Roche
Active, not recruiting
Phase 1/2
Hoffmann-La Roche
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
12/27/2017
Primary completion :
09/30/2025
Completion :
11/30/2026
PD-L1
|
PD-L1 expression
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • carboplatin • gemcitabine • docetaxel • Cotellic (cobimetinib) • pemetrexed • ipatasertib (RG7440) • Trodelvy (sacituzumab govitecan-hziy) • Actemra IV (tocilizumab) • tiragolumab (RG6058) • Repatha (evolocumab) • camonsertib (RP-3500) • cibisatamab (RG7802) • ciforadenant (CPI-444) • zanzalintinib (XL092)
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05487235)
Phase 1
Genentech, Inc.
Genentech, Inc.
Active, not recruiting
Phase 1
Genentech, Inc.
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
08/17/2022
Primary completion :
03/31/2026
Completion :
03/31/2026
EGFR • BRAF • ALK
|
PD-L1 expression • BRAF wild-type
|
Tecentriq (atezolizumab) • migoprotafib (RLY-1971) • omeprazole
A Study of Tobemstomig + Nab-Paclitaxel Compared With Pembrolizumab + Nab-Paclitaxel in Participants With Previously Untreated, PD-L1-Positive, Locally-Advanced Unresectable or Metastatic Triple-Negative Breast Cancer (NCT05852691)
Phase 2
Hoffmann-La Roche
Hoffmann-La Roche
Active, not recruiting
Phase 2
Hoffmann-La Roche
Active, not recruiting
Last update posted :
02/19/2025
Initiation :
07/18/2023
Primary completion :
12/24/2026
Completion :
12/24/2026
HER-2 • PD-L1 • ER • CD4
|
PD-L1 expression
|
Keytruda (pembrolizumab) • albumin-bound paclitaxel • tobemstomig (RG6139)
Phase III Study of Toripalimab(JS001) Combined With Lenvatinib for Advanced HCC (JS001-027-III-HCC) (NCT04523493)
Phase 3
Shanghai Junshi Bioscience Co., Ltd.
Shanghai Junshi Bioscience Co., Ltd.
Active, not recruiting
Phase 3
Shanghai Junshi Bioscience Co., Ltd.
Active, not recruiting
Last update posted :
02/19/2025
Initiation :
06/29/2020
Primary completion :
05/31/2025
Completion :
09/01/2026
PD-L1 • TMB
|
PD-L1 expression
|
Lenvima (lenvatinib) • Loqtorzi (toripalimab-tpzi)
Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative (NCT04929041)
Phase 2/3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 2/3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/19/2025
Initiation :
10/07/2022
Primary completion :
12/31/2027
Completion :
12/31/2027
EGFR • PD-L1 • ALK • ROS1
|
PD-L1 expression • ALK mutation
|
Keytruda (pembrolizumab) • Opdivo (nivolumab) • Yervoy (ipilimumab) • carboplatin • paclitaxel • albumin-bound paclitaxel • pemetrexed • ABP 206 (nivolumab biosimilar) • Pembroria (pembrolizumab biosimilar) • Pemfexy (pemetrexed)
Study of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC (NCT04093167)
Phase 2/3
Canadian Cancer Trials Group
Canadian Cancer Trials Group
Recruiting
Phase 2/3
Canadian Cancer Trials Group
Recruiting
Last update posted :
02/19/2025
Initiation :
05/26/2020
Primary completion :
12/31/2026
Completion :
07/30/2027
EGFR • PD-L1 • ALK
|
PD-L1 expression
|
Keytruda (pembrolizumab)
Ph II Study of Pembrolizumab & Eribulin in Patients With HR+/HER2- MBC Previously Treated With Anthracyclines & Taxanes (KELLY) (NCT03222856)
Phase 2
MedSIR
MedSIR
Completed
Phase 2
MedSIR
Completed
Last update posted :
02/19/2025
Initiation :
12/14/2017
Primary completion :
10/31/2018
Completion :
12/23/2020
HER-2 • PD-L1 • ER • PGR • TMB
|
PD-L1 expression • HER-2 positive • HR positive • HER-2 negative • HR positive + HER-2 negative
|
Keytruda (pembrolizumab) • Halaven (eribulin mesylate)
Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy (NCT06439836)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Not yet recruiting
Phase 1
National Cancer Institute (NCI)
Not yet recruiting
Last update posted :
02/18/2025
Initiation :
02/21/2025
Primary completion :
06/01/2027
Completion :
06/01/2027
PD-L1 • CD68 • CRP
|
PD-L1 expression
|
Keytruda (pembrolizumab) • emavusertib (CA-4948)
Sasanlimab (PF-06801591, PD-1 Inhibitor) in Participants With Advanced Malignancies (NCT04181788)
Phase 2
Pfizer
Pfizer
Active, not recruiting
Phase 2
Pfizer
Active, not recruiting
Last update posted :
02/18/2025
Initiation :
03/18/2020
Primary completion :
03/03/2022
Completion :
04/30/2025
EGFR • PD-L1 • BRAF • ALK • ROS1
|
PD-L1 expression • EGFR mutation • BRAF mutation • ALK translocation
|
sasanlimab (PF-06801591)
A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors (ST316-101) (NCT05848739)
Phase 1
Sapience Therapeutics
Sapience Therapeutics
Recruiting
Phase 1
Sapience Therapeutics
Recruiting
Last update posted :
02/17/2025
Initiation :
06/05/2023
Primary completion :
05/31/2026
Completion :
05/31/2027
PD-L1 • MSI • BRCA
|
PD-L1 expression • MSI-H/dMMR • BRCA mutation
|
Avastin (bevacizumab) • 5-fluorouracil • irinotecan • Fruzaqla (fruquintinib) • Lonsurf (trifluridine/tipiracil) • leucovorin calcium • ST316
Durvalumab and Tremelimumab in Patients With Advanced Rare Tumours (NCT02879162)
Phase 2
Canadian Cancer Trials Group
Canadian Cancer Trials Group
Completed
Phase 2
Canadian Cancer Trials Group
Completed
Last update posted :
02/17/2025
Initiation :
12/14/2016
Primary completion :
06/20/2021
Completion :
01/29/2025
PD-L1
|
PD-L1 expression
|
Imfinzi (durvalumab) • Imjudo (tremelimumab-actl)
Evaluation of Programmed Death Ligand 1 (PDL1) Response to Treatment in Patient-derived Organoids and Immune-marker Positron Emission Tomography (PET) Scanning in Non-small Cell Lung Cancer (NSCLC) (NCT06405230)
Phase 1/2
GlaxoSmithKline
GlaxoSmithKline
Not yet recruiting
Phase 1/2
GlaxoSmithKline
Not yet recruiting
Last update posted :
02/17/2025
Initiation :
02/28/2025
Primary completion :
12/16/2027
Completion :
06/01/2028
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • cisplatin • carboplatin • pemetrexed • Jemperli (dostarlimab-gxly)
Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET) (NCT05700721)
Phase 2
M.D. Anderson Cancer Center
M.D. Anderson Cancer Center
Recruiting
Phase 2
M.D. Anderson Cancer Center
Recruiting
Last update posted :
02/17/2025
Initiation :
06/02/2023
Primary completion :
08/07/2025
Completion :
08/07/2027
PD-L1 • HRD • CDK12 • CHEK2 • RAD51 • RAD51B • BRIP1 • RAD51C • RAD51D • CHEK1 • RAD54L • FANCL • RAD52
|
PD-L1 expression
|
Zejula (niraparib) • Jemperli (dostarlimab-gxly)
Camu-Camu Prebiotic and Immune Checkpoint Inhibition in Patients With Non-small Cell Lung Cancer and Melanoma (NCT05303493)
Phase 1
Centre hospitalier de l'Université de Montréal (CHUM)
Centre hospitalier de l'Université de M...
Recruiting
Phase 1
Centre hospitalier de l'Université de Montréal ...
Recruiting
Last update posted :
02/14/2025
Initiation :
06/29/2022
Primary completion :
04/15/2025
Completion :
04/15/2027
PD-L1 • BRAF
|
PD-L1 expression
|
Keytruda (pembrolizumab) • Opdivo (nivolumab)
Study of BGB-A425 and LBL-007 in Combination With Tislelizumab in Advanced Solid Tumors (BGB-900-102) (NCT03744468)
Phase 1/2
BeiGene
BeiGene
Completed
Phase 1/2
BeiGene
Completed
Last update posted :
02/14/2025
Initiation :
11/13/2018
Primary completion :
02/06/2025
Completion :
02/06/2025
PD-L1
|
PD-L1 expression
|
Tevimbra (tislelizumab-jsgr) • alcestobart (LBL-007) • surzebiclimab (BGB-A425)
Tislelizumab in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Gastric, or Gastroesophageal Junction Carcinoma (RATIONALE 305) (NCT03777657)
Phase 3
BeiGene
BeiGene
Completed
Phase 3
BeiGene
Completed
Last update posted :
02/14/2025
Initiation :
12/13/2018
Primary completion :
02/28/2023
Completion :
08/27/2024
PD-L1
|
PD-L1 expression
|
cisplatin • 5-fluorouracil • Tevimbra (tislelizumab-jsgr) • capecitabine • oxaliplatin
Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) (MK-7902-007/E7080-G000-314/LEAP-007) (NCT03829332)
Phase 3
Merck Sharp & Dohme LLC
Merck Sharp & Dohme LLC
Completed
Phase 3
Merck Sharp & Dohme LLC
Completed
Last update posted :
02/14/2025
Initiation :
03/13/2019
Primary completion :
05/19/2021
Completion :
04/24/2024
PD-L1
|
PD-L1 expression
|
Keytruda (pembrolizumab) • Lenvima (lenvatinib)
Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors (NCT02496208)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 1
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/13/2025
Initiation :
07/22/2015
Primary completion :
09/30/2026
Completion :
09/30/2026
PD-L1
|
PD-L1 expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • CS1002 (ipilimumab biosimilar) • ABP 206 (nivolumab biosimilar) • CMAB 819 (nivolumab biosimilar)
Denosumab and Nivolumab Combination As 2d-line Therapy in Stage IV NSC Lung Cancer with Bone Metastases (DENIVOS) (NCT03669523)
Phase 2
Centre Hospitalier Annecy Genevois
Centre Hospitalier Annecy Genevois
Completed
Phase 2
Centre Hospitalier Annecy Genevois
Completed
Last update posted :
02/13/2025
Initiation :
11/06/2018
Primary completion :
10/19/2023
Completion :
10/19/2023
EGFR • PD-L1 • BRAF • ALK
|
PD-L1 expression • EGFR mutation • BRAF mutation • BRAF V600 • ALK translocation
|
Opdivo (nivolumab) • Prolia (denosumab) • zoledronic acid
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer (NeoCOAST-2) (NCT05061550)
Phase 2
AstraZeneca
AstraZeneca
Recruiting
Phase 2
AstraZeneca
Recruiting
Last update posted :
02/13/2025
Initiation :
04/14/2022
Primary completion :
05/09/2030
Completion :
05/09/2030
EGFR • PD-L1 • ALK
|
PD-L1 expression
|
cisplatin • carboplatin • Imfinzi (durvalumab) • paclitaxel • pemetrexed • Datroway (datopotamab deruxtecan) • oleclumab (MEDI9447) • rilvegostomig (AZD2936) • volrustomig (MEDI5752) • falbikitug (AZD0171) • monalizumab (IPH2201)
A Study of AZD2936 Anti-TIGIT/Anti-PD-1 Bispecific Antibody in Participants With Advanced or Metastatic NSCLC (ARTEMIDE-01) (NCT04995523)
Phase 1/2
AstraZeneca
AstraZeneca
Recruiting
Phase 1/2
AstraZeneca
Recruiting
Last update posted :
02/13/2025
Initiation :
09/14/2021
Primary completion :
08/18/2026
Completion :
03/16/2028
PD-L1
|
PD-L1 expression
|
rilvegostomig (AZD2936)
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