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    TEST:
    PDGFRB FISH Assay

    Company:
    ARUP Laboratories
    Type:
    FDA Approved
    Details
    Evidence

    News

    over2years
    Myeloid/Lymphoid Neoplasm with Eosinophilia and a Novel RUFY1-Pdgfrb Rearrangement (ASH 2021)
    Initial treatment included high dose steroids for 7 days and hydroxyurea briefly...Six weeks after starting imatinib he had renal recovery and has achieved a complete hematologic response except for mild anemia due to resolving acute kidney injury...These reports and ours highlight the clinical relevance of NGS in identifying novel rearrangement partners. Furthermore, patient-specific ddPCR assays can be designed for sensitive monitoring.
    PDGFRB (Platelet Derived Growth Factor Receptor Beta) • ETV6 (ETS Variant Transcription Factor 6) • G3BP1 (G3BP Stress Granule Assembly Factor 1)
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    PDGFRB FISH Assay
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    imatinib • hydroxyurea
    over3years
    [VIRTUAL] Whole genome profiling of adult B‐other acute lymphoblastic leukaemia on the UKALL14 trial (BSH-I 2020)
    Distinct classes of genomic instability are identified in B‐other ALL this include a RAG mutation phenotype, high SV burden and MMR hypermutator. This approach sets the premise to design an extended genotype‐clinical correlative study on B‐ALL cases enrolled in UKALL14 and 60+ trials.
    Clinical • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • ABL1 (ABL proto-oncogene 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • FGFR1 (Fibroblast growth factor receptor 1) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • JAK2 (Janus kinase 2) • ASXL1 (ASXL Transcriptional Regulator 1) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • ETV6 (ETS Variant Transcription Factor 6) • CRLF2 (Cytokine Receptor Like Factor 2) • IKZF1 (IKAROS Family Zinc Finger 1) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • PAX5 (Paired Box 5) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • P2RY8 (P2Y Receptor Family Member 8) • ABL2 (ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase)
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    IDH2 mutation • ASXL1 mutation • IDH2 R140Q
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    PDGFRB FISH Assay