TEST:

nCounter® miRNA Expression Assay Kit

Furthermore, we found 26 miRNA target genes for four of the five identified miRNAs, mainly related to pathways in cancer, RNA Polymerase II Transcription, RhoA signaling pathway, and PI3K-Akt signaling pathway. Conclusions This study demonstrated that those miRNAs could be used as non-invasive biomarkers in LBC samples, once they were able to distinguish CIN 2 and CIN3 patients from healthy women and regulate important molecular pathways of onset carcinogenesis.