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    4ms
    EV-miRNAs from breast cancer patients of plasma as potential prognostic biomarkers of disease recurrence. (PubMed, Heliyon)
    The prognostic significance of EVs is closely tied to the unique expression profiles of miR-19a-3p and miR-130b-3p. These findings underscore the potential of EV-associated miRNAs as valuable indicators for BC recurrence, opening new avenues for diagnosis and treatment exploration.
    Journal
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    PTEN (Phosphatase and tensin homolog) • MDM4 (The mouse double minute 4) • MIR19A (MicroRNA 19a)
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    nCounter® miRNA Expression Assay Kit
    over1year
    Cell-free tumor microRNA as early biomarkers of high-grade cervical intraepithelial neoplasia using liquid biopsy (ESMO 2023)
    Furthermore, we found 26 miRNA target genes for four of the five identified miRNAs, mainly related to pathways in cancer, RNA Polymerase II Transcription, RhoA signaling pathway, and PI3K-Akt signaling pathway. Conclusions This study demonstrated that those miRNAs could be used as non-invasive biomarkers in LBC samples, once they were able to distinguish CIN 2 and CIN3 patients from healthy women and regulate important molecular pathways of onset carcinogenesis.
    Liquid biopsy • Biopsy
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    RHOA (Ras homolog family member A)
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    nCounter® miRNA Expression Assay Kit