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Laboratory Developed Test
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HER2DX measures the RNA levels of 27 genes, using an intelligent analytical software to divide patients into high and low risk groups, by giving them a score from 0 to 100. It does this by capturing the four crucial biological processes of HER2+ breast cancer: 1) activation of the immune system within the tumor, 2) the differentiated status of tumor cells, 3) the proliferation status of the tumor, and 4) the expression of the HER2 gene and several neighboring genes on chromosome 17. The information provided by the 27 genes, along with tumor size and axillary node involvement, is used to supply two types of clinical information: 1) patient prognosis and 2) tumor sensitivity to chemotherapy and HER2 treatments given prior to tumor surgery.
Breast Cancer
HER-2 (Human epidermal growth factor receptor 2)