The BostonGene Tumor Portrait Test is highly predictive of response to immunotherapy and stratifies patients into responders and non-responders. This information will aid physicians with therapy selection, decrease unnecessary adverse events, and allow healthcare systems to reduce expenditures significantly. For patients classified as non-responders to immunotherapy, the BostonGene Tumor Portrait Test provides other potential therapy options, utilizing existing guidelines to equip the treating physician in selecting the ideal therapy route.