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    GENE:

    ZWINT (ZW10 Interacting Kinetochore Protein)

    i
    Other names: ZWINT, ZW10 Interacting Kinetochore Protein, ZW10 Interactor, KNTC2AP, SIP30, SNAP25 Interacting Protein Of 30 KDa, Zwint-1, Zwint1, ZW10 Interactor, Kinetochore Protein, Human ZW10 Interacting Protein-1, ZW10-Interacting Protein 1, HZwint-1, ZWINT1
    Associations

    News

    Trials
    2ms
    Radiotherapy and precision medicine's role in molecular alterations during chromosomal division: The influence of MB, TP53, CENPA, BUB1B, MAD2L1, ZWINT expression and noncoding RNAs in oral cancer. (PubMed, Biochem Biophys Rep)
    Additionally, we explore the potential of targeting these molecules to enhance the efficacy of radiation therapy and improve patient outcomes. Our study contributes to the comprehension of the molecular processes underlying oral cancer and provides insights into the development of novel therapeutic strategies based on personalized medicine.
    Journal
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    TP53 (Tumor protein P53) • MIR361 (MicroRNA 361) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CENPA (Centromere protein A) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MIR122 (MicroRNA 122) • ZWINT (ZW10 Interacting Kinetochore Protein)
    5ms
    Plumbagin remodels the tumor immune microenvironment to overcome cisplatin resistance in tongue squamous cell carcinoma via KLF2 activation and ZWINT/NF-κB inhibition. (PubMed, Int Immunopharmacol)
    These dual actions-tumor chemosensitization via ZWINT/NF-κB inhibition and immune reprogramming via KLF2 activation-were functionally interconnected, as cytokines released by PLB-primed T cells reinforced NF-κB suppression in tumor cells. Collectively, our findings identify PLB as a low-cost small molecule that integrates cisplatin sensitization with immune activation, offering a promising adjunctive strategy for cisplatin-refractory TSCC.
    Journal
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    CD8 (cluster of differentiation 8) • JAK1 (Janus Kinase 1) • STAT2 (Signal transducer and activator of transcription 2) • ZWINT (ZW10 Interacting Kinetochore Protein)
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    cisplatin
    5ms
    ZWINT down-regulated by miR-495-3p inhibited lung metastasis of breast cancer by blocking p38 MAPK signaling pathway activation. (PubMed, Hum Cell)
    Our findings demonstrate that ZWINT drives breast cancer metastasis and is negatively regulated by miR-495-3p. The newly identified miR-495-3p/ZWINT/p38 MAPK axis may provide a promising therapeutic target for suppressing breast cancer progression.
    Journal
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    MIR495 (MicroRNA 495) • ZWINT (ZW10 Interacting Kinetochore Protein)
    5ms
    Data-Driven Discovery of a Key Regulator Cyclin A2 as a Promising Therapeutic Target in Hormone-Sensitive Cancers. (PubMed, Mol Biotechnol)
    The differentially expressed genes in each cancer type were compared with previously reported tamoxifen resistance-causing genes...The median CCNA2 expression level was 21.301 in stage IV BC patients, 38.481 in stage II ovarian cancer patients, and 23.206 in stage IV endometrial cancer patients. Thus, CCNA2 could be a potential therapeutic target for treating HSCs with endocrine therapy resistance.
    Journal
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    CXCR4 (Chemokine (C-X-C motif) receptor 4) • LYN (LYN Proto-Oncogene Src Family Tyrosine Kinase) • CCNA2 (Cyclin A2) • MYBL2 (MYB Proto-Oncogene Like 2) • CDCA8 (Cell Division Cycle Associated 8) • CDK3 (Cyclin Dependent Kinase 3) • E2F1 (E2F transcription factor 1) • ZWINT (ZW10 Interacting Kinetochore Protein)
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    tamoxifen
    8ms
    Regulation of Human Lung Adenocarcinoma Cell Proliferation by LncRNA AFAP-AS1 Through the miR-508/ZWINT Axis. (PubMed, Int J Mol Sci)
    AFAP1-AS1 accelerates the development of lung adenocarcinoma by cell proliferation, apoptosis, and invasion via the miR-508-3p/ZWINT axis. Thus, targeting AFAP1-AS1 or its downstream regulatory axis could offer novel therapeutic approaches in lung adenocarcinoma treatment.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • MIR508 (MicroRNA 508) • ZWINT (ZW10 Interacting Kinetochore Protein)
    8ms
    Association of ZWINT Expression with Clinicopathologic Characteristics and Prognosis in Breast Cancer Patients. (PubMed, Curr Med Sci)
    ZWINT may serve as a potential biomarker for prognosis and a possible therapeutic target alongside TP53/CDH1 in breast cancer.
    Journal
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    TP53 (Tumor protein P53) • CDH1 (Cadherin 1) • CDH2 (Cadherin 2) • ZWINT (ZW10 Interacting Kinetochore Protein)
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    TP53 mutation
    9ms
    NAmiRNA-31 regulates cell cycle by activating ZWINT and promotes lung adenocarcinoma tumor development. (PubMed, Technol Health Care)
    The transfection with miR-31mimic enhanced the activity of LUAD cells and promoted colony growth. Knockdown of ZWINT expression resulted in (G2 to mitosis)G2/M phase cell arrest, concurrent with a decrease in Cyclin B1 and (Cyclin-Dependent Kinase 1)CDK1 proteins.Conclusion(nuclear activating mirna-31)NAmiRNA-31 and ZWINT are upregulated in LUAD, suggest their potential as biomarkers for the unfavorable prognosis.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • MIR31 (MicroRNA 31) • CCNB1 (Cyclin B1) • ZWINT (ZW10 Interacting Kinetochore Protein)
    10ms
    Four genes shared between rheumatoid arthritis and cervical cancer are associated with cervical cancer prognosis. (PubMed, Sci Rep)
    Among them, CXCL1 stood out as especially crucial. Our findings suggest a potential link between chronic inflammation, immune dysregulation, and chemokine-related pathways in RA patients, which may contribute to an increased susceptibility to CC.
    Journal
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    CXCL13 (Chemokine (C-X-C motif) ligand 13) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • ZWINT (ZW10 Interacting Kinetochore Protein)
    1year
    High expression of H2AX/γ-H2AX is associated with distinct biological pathway alterations and shorter survival in oropharyngeal squamous cell carcinoma. (PubMed, Oral Oncol)
    H2AX/γ-H2AX expression is a potential prognostic biomarker in OPSCC, with elevated levels indicating poor survival, especially in HPV-negative cases. These findings suggest distinct molecular behaviors in OPSCC based on H2AX expression and highlight the need for further investigation into its therapeutic implications.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1) • H2AX (H2A.X Variant Histone) • ZWINT (ZW10 Interacting Kinetochore Protein)
    1year
    Identification of Tumor-Suppressive miR-30a-3p Controlled Genes: ANLN as a Therapeutic Target in Breast Cancer. (PubMed, Noncoding RNA)
    Finally, our assays demonstrated that the overexpression of ANLN had cancer-promoting functions in BC cells. The involvement of miR-30a-3p (the passenger strand) in BC molecular pathogenesis is a new concept in cancer research, and the outcomes of our study strongly indicate the importance of analyzing passenger strands of miRNAs in BC cells.
    Journal
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    EML4 (EMAP Like 4) • BIRC5 (Baculoviral IAP repeat containing 5) • CLTC (Clathrin Heavy Chain) • NCAPG (Non-SMC Condensin I Complex Subunit G) • RIF1 (Replication Timing Regulatory Factor 1) • ANLN (Anillin Actin Binding Protein) • CCNB1 (Cyclin B1) • E2F7 (E2F Transcription Factor 7) • KIF23 (Kinesin Family Member 23) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MIR30A (MicroRNA 30a) • SEPTIN10 (Septin 10) • ZWINT (ZW10 Interacting Kinetochore Protein)
    1year
    Identification of Diagnostic and Prognostic Subnetwork Biomarkers for Women with Breast Cancer Using Integrative Genomic and Network-Based Analysis. (PubMed, Int J Mol Sci)
    Moreover, the prognostic significance of these subnetwork markers was validated using independent transcriptomic datasets comprising over 4000 patients. These findings suggest that subnetwork markers derived from integrated genomic network analyses can enhance our understanding of the molecular landscape of breast cancer, potentially leading to improved diagnostic, prognostic, and therapeutic strategies.
    Journal
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    IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) • KIF4A (Kinesin Family Member 4A) • UBE2C (Ubiquitin Conjugating Enzyme E2 C) • ZWINT (ZW10 Interacting Kinetochore Protein)
    over1year
    Deciphering molecular landscape of breast cancer progression and insights from functional genomics and therapeutic explorations followed by in vitro validation. (PubMed, Sci Rep)
    It underscores the importance of hub genes and their potential interactions with therapeutic agents, particularly Fisetin. By shedding light on the interplay between CDK1 and DTL expression, our findings contribute to understanding the regulatory landscape of invasive ductal carcinoma and pave the way for future investigations and novel therapeutic avenues.
    Preclinical • Journal
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    CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • CDCA8 (Cell Division Cycle Associated 8) • IL17RB (Interleukin 17 Receptor B) • KIF2C (Kinesin Family Member 2C) • ZWINT (ZW10 Interacting Kinetochore Protein)