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    GENE:

    ZNF689 (Zinc Finger Protein 689)

    i
    Other names: ZNF689, Zinc Finger Protein 689, TIPUH1, Short ORF-Encoded Histone-Binding Protein, FLJ90415, Transcription-Involved Protein Upregulated In HCC, ZNF689 Upstream Open Reading Frame Protein, Transcriptional Regulator SEHBP
    2years
    ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer. (PubMed, Cell Res)
    Consistently, ZNF689 expression positively correlated with favorable prognosis and immunotherapy response in clinical samples. Altogether, our study uncovers a previously unrecognized mechanism underlying ZNF689 deficiency-induced ITH and suggests LINE-1 inhibition combined with immunotherapy as a novel treatment strategy for TNBC.
    Journal • IO biomarker
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    ZNF689 (Zinc Finger Protein 689) • TRIM28 (Tripartite Motif Containing 28)