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    GENE:

    ZNF649-AS1 (ZNF649 Antisense RNA 1)

    i
    Other names: ZNF649-AS1, ZNF649 Antisense RNA 1
    over1year
    LncRNA ZNF649-AS1 promotes trastuzumab resistance and TAM-dependent PD-L1 expression in breast cancer by regulating EXOC7 alternative splicing. (PubMed, Arch Biochem Biophys)
    ZNF649-AS1 promoted trastuzumab resistance and TAM-dependent PD-L1 expression in HER2-positive BC via promoting alternative splicing of EXOC7 by PRPF8.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • CD68 (CD68 Molecule) • MRC1 (Mannose Receptor C-Type 1) • ZNF649-AS1 (ZNF649 Antisense RNA 1) • PRPF8 (Pre-MRNA Processing Factor 8)
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    Herceptin (trastuzumab)