ZIC2 (Zic Family Member 2)

ZIC2 may serve as a valuable prognostic and prognostic biomarker in pan-cancer, including CRC. ZIC2 may promote the colorectal cancer progression by upregulating QPRT.

Moreover, some functional pathways were identified in the high-risk group in the low-risk group. We developed a novel five-gene prognostic model centered on Hedgehog signaling pathway-related genes, which holds potential as a valuable prognostic tool for HCC and may provide guidance for immunotherapy selection.

The index related to TTK appears to be a valuable biomarker for effectively assessing survival and forecasting the success of therapy in patients with BRCA. This risk metric can enable timely and targeted early interventions for patients, thus promoting advancements in personalized medicine and enhancing the research in precise immuno-oncology.

The study highlights the pivotal role of M1 macrophage-related DEGs in LUSC tumorigenesis. The newly identified 5 hub genes provide a highly accurate diagnostic tool for LUSC, offering potential improvements for both diagnostic and therapeutic strategies.

Additionally, drugs like AUY922 and AZ628 showed considerable potential in treating BC. RT-qPCR results for these four genes in clinical samples aligned with the bioinformatics findings. This study identified and validated four prognostic genes-ZIC2, CD24, CEBPD, and CCL19-that are associated with BC and may provide novel targets for diagnostic and therapeutic strategies.

The association of ZIC2 and METTL3 was identified by m6A RNA immunoprecipitation assay, dual-luciferase reporter gene assay, Actinomycin D assay and co-immunoprecipitation assay...Further,METTL3 deficiency repressed OS cell malignancy by reducing ZIC2expression. METTL3-mediated m6Amodification of ZIC2 contributed to OS development, providing therapeutic targets for OS.

Using CRISPR-Cas9 to knock out ZIC2 also prevented tumor formation in nude mice. These results emphasize the critical role of MTF1 in the oncogenic process and its involvement in the ZIC2-mediated transformation associated with Cd-induced malignant changes.

The nomogram prognostic prediction model, consisting of ITPKA, PDIA2, SAA2, SHOX2, TREML3P, and ZIC2, is capable of predicting the prognosis of ccRCC patients. Among them, SAA2 promotes the proliferation, migration, and invasion of ccRCC cells.

These results demonstrate SWI/SNF complexes are critical for lineage-specific TF binding and activity at both promoters and enhancers. In the context of ATRT, these findings reveal a previously underappreciated therapeutic vulnerability in targeting residual promoter-proximal TF function in ATRT.

These results suggest that CTMP induces cell senescence and that Zic2 is a suppressor of CTMP expression. The decrease of Zic2 contributes to CTMP increase with aging.

Our study established a six-gene model for predicting breast cancer prognosis. Furthermore, we unexpectedly discovered that CXCL9 is integral to immune infiltration in breast cancer and may serve as a critical biomarker for evaluating immune response and therapeutic efficacy in breast cancer treatment.