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GENE:

ZFHX3 (Zinc Finger Homeobox 3)

News alerts, weekly reports and conference planners

2ms

Integrating multi-omics and clinical features to model survival in epithelial ovarian cancer subtypes. (PubMed, Sci Rep)

Integrating multivariate predictive modeling with biological interpretation provides a comprehensive framework for personalized risk stratification and treatment decision-making in EOC. The identified prognostic biomarkers, such as TPM4, SDHD, MUC16, and BCL6, represent potential targets for future studies and therapeutic interventions.

2 months ago

Journal

TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog) • ARID1A (AT-rich interaction domain 1A) • BCL6 (B-cell CLL/lymphoma 6) • WT1 (WT1 Transcription Factor) • MUC16 (Mucin 16, Cell Surface Associated) • FAT3 (FAT Atypical Cadherin 3) • ZFHX3 (Zinc Finger Homeobox 3) • FAT4 (FAT Atypical Cadherin 4) • CSMD3 (CUB And Sushi Multiple Domains 3) • HOXA11 (Homeobox A11) • SDHD (Succinate Dehydrogenase Complex Subunit D) • TPM4 (Tropomyosin 4)

TP53 mutation • PIK3CA mutation • PTEN mutation • ARID1A mutation

4ms

HOXB13 interactome in prostate cancer cells: biochemical and functional interactions between the transcription factors HOXB13 and TBX3. (PubMed, Vavilovskii Zhurnal Genet Selektsii)

Analysis of individual prostate cancer cell lines revealed that knockout of both genes, HOXB13 and TBX3, leads to the death of the same lines: VCaP, LNCaP (clone FGC), PC-3 and 22Rv1. Thus, HOXB13 and TBX3 can be considered together as potential targets for the development of specific inhibitors that suppress prostate cancer cell growth.

4 months ago

Journal

RUNX1 (RUNX Family Transcription Factor 1) • ZFHX3 (Zinc Finger Homeobox 3) • HOXB13 (Homeobox B13) • ZFHX4 (Zinc Finger Homeobox 4)

5ms

Genetics-Driven, Intensity-Modulated Adaptive Management of Patients With Metastatic Prostate Cancer. (PubMed, Prostate)

We identified 65 site-specific multigene clusters-chiefly in lymph node-only mPC-that underlie the survival gap between nodal and bone metastases. These signatures suggest a 10-60-month interval that may lend itself for intensity-modulated follow-up. We also discovered hundreds of synthetic-lethal gene-alteration pairs, opening future research opportunities in combinatorial therapeutic targeting.

5 months ago

Journal

PTEN (Phosphatase and tensin homolog) • CDK12 (Cyclin dependent kinase 12) • KMT2C (Lysine Methyltransferase 2C) • FOXA1 (Forkhead Box A1) • ZFHX3 (Zinc Finger Homeobox 3) • TMPRSS2 (Transmembrane serine protease 2)

7ms

Pathogenic Genomic Alterations in Circulating Tumor DNA Predict Overall Survival in Men with Metastatic Castrate-resistant Prostate Cancer. (PubMed, Eur Urol)

Incorporation of PGAs from ctDNA into a CG model improved OS prediction by nearly 30% over a clinical model. This model can classify patients into risk groups and is useful for selecting patients in future mCRPC trials.

7 months ago

Journal • Circulating tumor DNA

BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • AR (Androgen receptor) • RB1 (RB Transcriptional Corepressor 1) • CCND1 (Cyclin D1) • MSH6 (MutS homolog 6) • FANCA (FA Complementation Group A) • ZFHX3 (Zinc Finger Homeobox 3) • CHD1 (Chromodomain Helicase DNA Binding Protein 1) • PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) • RSPO2 (R-Spondin 2) • ZBTB16 (Zinc Finger And BTB Domain Containing 16) • NKX3-1 (NK3 homeobox 1)

8ms

ZFHX3 is integral to androgen/AR signaling involving protein association with AR in prostate cancer cells. (PubMed, Sci Rep)

ZFHX3 loss promoted cell proliferation/colony formation and attenuated enzalutamide's efficacy...These findings suggest that ZFHX3 is integral for AR signaling in prostate epithelial cells. ZFHX3 loss, which occurs in advanced prostate cancer, affects AR's function in gene transcription and could thus compromise PSA/KLK3 utility in prostate cancer detection.

8 months ago

Journal

ZFHX3 (Zinc Finger Homeobox 3) • FKBP5 (FKBP Prolyl Isomerase 5) • KLK3 (Kallikrein-related peptidase 3)

Xtandi (enzalutamide)

8ms

Feasibility of long-read sequencing to identify molecular alterations in an Indonesian cohort of locally advanced to advanced nasopharyngeal cancer. (PubMed, Sci Rep)

Extensive DNA repair gene defects, primarily complex SVs detectable by long reads, were observed and highly possibly associated with poor survival. These findings underscore the potential of long-read sequencing for uncovering clinically relevant mutations in NPC.

8 months ago

Journal

FADD (Fas associated via death domain) • ZFHX3 (Zinc Finger Homeobox 3) • CASP8 (Caspase 8) • EPHA3 (EPH receptor A3) • CDKN1C (Cyclin Dependent Kinase Inhibitor 1C) • IRF5 (Interferon Regulatory Factor 5)

10ms

The transcription factor TSHZ3 promotes tumor immunosuppression and inhibits metastasis in lung adenocarcinoma. (PubMed, Front Immunol)

In addition, CCL2 expression was significantly higher in LUAD cells overexpressing TSHZ3, while CCR2 expression was also significantly upregulated in co-cultured macrophages. These findings suggest that TSHZ3 is an important tumor suppressor by inhibiting EMT and metastasis while inducing apoptosis through M1 macrophage chemotaxis via the CCL2/CCR2.

10 months ago

Journal

ZFHX3 (Zinc Finger Homeobox 3) • CCL2 (Chemokine (C-C motif) ligand 2) • CCR2 (C-C Motif Chemokine Receptor 2) • CD86 (CD86 Molecule)

11ms

Distinct genomic features and mutational signatures of nucleotide excision repair and mismatch repair in thymoma. (PubMed, Am J Cancer Res)

Furthermore, we identified mismatch repair deficiency as a Taiwanese population-specific mutational signature with higher activity. These results highlight the distinct genomic background and molecular mechanisms of thymoma in the Taiwanese population, which may contribute to the development of new diagnostic and therapeutic strategies in the future.

11 months ago

Journal • Mismatch repair • Tumor mutational burden

TMB (Tumor Mutational Burden) • KMT2D (Lysine Methyltransferase 2D) • FAT1 (FAT atypical cadherin 1) • ZFHX3 (Zinc Finger Homeobox 3)

11ms

Hydroa vacciniforme lymphoproliferative disorder, a clinicopathologic and genetic analysis. (PubMed, Hum Pathol)

Most patients were treated with immunomodulating therapy, two received methotrexate, three received multiagent chemotherapy and one underwent hematopoietic stem cell transplant...Our results showed that patients with persistent/progressive systemic HV-LPD have a poor prognosis and do not respond well to chemotherapy. The mutation spectrum bore some resemblance to extranodal NK/T lymphomas but also had notable differences.

11 months ago

Journal

TP53 (Tumor protein P53) • CD20 (Membrane Spanning 4-Domains A1) • CD8 (cluster of differentiation 8) • TNFRSF8 (TNF Receptor Superfamily Member 8) • TET2 (Tet Methylcytosine Dioxygenase 2) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • CREBBP (CREB binding protein) • BCOR (BCL6 Corepressor) • KDM6A (Lysine Demethylase 6A) • NCAM1 (Neural cell adhesion molecule 1) • IRF8 (Interferon Regulatory Factor 8) • RHOA (Ras homolog family member A) • STAT5B (Signal Transducer And Activator Of Transcription 5B) • NCOR1 (Nuclear Receptor Corepressor 1) • NCOR2 (Nuclear Receptor Corepressor 2) • ZFHX3 (Zinc Finger Homeobox 3) • GZMB (Granzyme B) • IRF4 (Interferon regulatory factor 4) • PRDM1 (PR/SET Domain 1) • ALPK2 (Alpha Kinase 2) • BCORL1 (BCL6 Corepressor Like 1) • DDX3X (DEAD-Box Helicase 3 X-Linked)

TP53 mutation • CD20 positive • TET2 mutation

methotrexate

11ms

Stochastically Emergent Tumors offer in vivo whole genome interrogation of cancer evolution from non-malignant precursors. (PubMed, bioRxiv)

We identified three novel genetic drivers (ZFHX3, CIC, KMT2D) of differential prostate cancer therapy responses. These alterations are enriched in patients of African and Chinese ancestry and correlate with significant differences in survival.

11 months ago

Preclinical • Journal

KMT2D (Lysine Methyltransferase 2D) • ZFHX3 (Zinc Finger Homeobox 3)

11ms

Clonal Hematopoietic Mutations in Plasma Cell Disorders: Clinical Subgroups and Shared Pathogenesis. (PubMed, Genomics Proteomics Bioinformatics)

Also, the poor PFS associated with MGA or SYNE1 mutations was confirmed across MM, AL, and POEMS. CH mutations partially explained the shared pathogenesis of MM, AL, POEMS, and MGUS, and helped identify patient subgroups with specific clinical features.

11 months ago

Journal

KMT2D (Lysine Methyltransferase 2D) • FAT1 (FAT atypical cadherin 1) • ZFHX3 (Zinc Finger Homeobox 3) • SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1)

1year

Genomic landscape and potential therapeutic targets in alpha-fetoprotein-producing gastric cancer. (PubMed, Gastric Cancer)

Furthermore, LRP1B and ARID1A have been identified as prognostic factors associated with overall survival (OS) and disease-free survival (DFS), respectively. Our results aim to improve AFPGC diagnosis by identifying potential therapeutic targets and prognostic factors, which could help facilitate the development of new treatment strategies.

1 year ago

Journal

EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • ARID1A (AT-rich interaction domain 1A) • CCNE1 (Cyclin E1) • LRP1B (LDL Receptor Related Protein 1B) • AFP (Alpha-fetoprotein) • GPC3 (Glypican 3) • ZFHX3 (Zinc Finger Homeobox 3) • MME (Membrane Metalloendopeptidase) • CDX2 (Caudal Type Homeobox 2) • SALL4 (Spalt Like Transcription Factor 4)

TP53 mutation • AFP elevation