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GENE:

ZEB1 (Zinc Finger E-box Binding Homeobox 1)

News alerts, weekly reports and conference planners

Differential effect of Periodontal pathogen Fusobacterium nucleatum and Porphyromonas gingivalis on modulation of specific partial-EMT genes in colorectal cancer cells. (PubMed, J Oral Biol Craniofac Res)

Elevated mRNA levels of EMP3, THBS2, and ITGA5 were significantly correlated with poorer overall survival. Fn and Pg can promote invasive phenotypes in CRC through distinct mechanisms, each modulating a unique subset of p-EMT and without instigating a complete, coordinated EMT gene signature.

6 days ago

Journal

SPP1 (Secreted Phosphoprotein 1) • MMP9 (Matrix metallopeptidase 9) • ITK (IL2 Inducible T Cell Kinase) • SNAI1 (Snail Family Transcriptional Repressor 1) • THBS2 (Thrombospondin 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • ITGA5 (Integrin Subunit Alpha 5) • MMP3 (Matrix metallopeptidase 3) • P4HA2 (Prolyl 4-Hydroxylase Subunit Alpha 2)

11d

A smart 3D microfluidic tumor spheroid-vessel co-culture model for studying exosomal HSP-mediated tumor invasion and angiogenesis. (PubMed, Lab Chip)

Conversely, HSP-depleted exosomes (ExosomeHSP del) reversed these effects, confirming that exosomal HSPs serve as critical mediators of tumor invasion and angiogenesis. This microfluidic model provides a physiologically relevant tool for studying metastatic mechanisms and screening therapeutic targets, highlighting exosomal HSPs as a promising intervention point.

11 days ago

Journal

CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)

11d

ZEB1 Promotes Alternate Lengthening of Telomeres at Multiple Levels. (PubMed, Cancers (Basel))

These findings suggest a novel role for ZEB1 in promoting ALT both transcriptionally and post-transcriptionally at multiple levels.

11 days ago

Journal

POLD1 (DNA Polymerase Delta 1) • WRN (WRN RecQ Like Helicase) • ESRP1 (Epithelial Splicing Regulatory Protein 1) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • RPA3 (Replication Protein A3) • SLX4 (SLX4 Structure-Specific Endonuclease Subunit)

11d

Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))

Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.

11 days ago

Review • Journal

MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)

14d

The Critical Role of Epithelial-Mesenchymal Transition (EMT) in Colorectal Cancer Progression and Therapeutic Outcomes. (PubMed, Crit Rev Oncol Hematol)

Emerging therapeutic strategies targeting EMT-associated signaling, epigenetic plasticity, and EMT-immune interactions are discussed, alongside the potential of liquid biopsy approaches to dynamically monitor EMT states during treatment. A refined understanding of epithelial-mesenchymal plasticity and hybrid EMT states is essential for the development of rational combination therapies and biomarker-guided strategies aimed at overcoming therapeutic resistance and limiting metastatic progression in colorectal cancer.

14 days ago

Review • Journal • IO biomarker

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • TGFB1 (Transforming Growth Factor Beta 1) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)

15d

TMEPAI Confers Paclitaxel Resistance in Triple-Negative Breast Cancer Cells by Promoting AKT Phosphorylation and Its Downstream Cascade. (PubMed, Asian Pac J Cancer Prev)

TMEPAI appears to facilitate paclitaxel resistance in triple-negative breast cancer cells by promoting cell survival signaling, inhibiting apoptosis, enhancing drug efflux, and initiating epithelial-mesenchymal transition (EMT). Targeting TMEPAI may be a viable approach to overcoming resistance and improving treatment outcomes in triple-negative breast cancer cells.

15 days ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • TGFB1 (Transforming Growth Factor Beta 1) • CASP9 (Caspase 9) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)

paclitaxel

15d

Crosstalk between ZEB1 expression and CD163+ Tumor-Associated Macrophages in Muscle-Invasive Urothelial Carcinoma. (PubMed, Asian Pac J Cancer Prev)

Elevated ZEB1 expression is strongly associated with poor prognosis in BC and closely correlated with an increased density of CD163+TAMs, further contributing to adverse outcomes. These findings highlight the potential of ZEB1 as a prognostic biomarker and underscore the therapeutic relevance of targeting TAMs in the management of BC.

15 days ago

Retrospective data • Journal

CD163 (CD163 Molecule) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)

18d

Astragalus polysaccharide enhances the antitumor efficacy of sunitinib in renal cell carcinoma by targeting the ZEB1-SCD1-Wnt/β-Catenin signaling pathway. (PubMed, Int J Biol Macromol)

Clinical data further verified that high ZEB1 expression is associated with poor prognosis in RCC and that ZEB1 promotes tumor progression by regulating SCD1 to activate the Wnt signaling pathway. In conclusion, APS enhances the sensitivity of RCC to sunitinib by targeting the ZEB1-SCD1-Wnt axis, thus providing a theoretical basis for the clinical application of this combined therapy.

18 days ago

Journal

ZEB1 (Zinc Finger E-box Binding Homeobox 1)

sunitinib

19d

Stemness and EMT profiles shift in xenografts derived from cisplatin-sensitive and cisplatin-tolerant ovarian cancer cells. (PubMed, PLoS One)

Our data further indicate that xenografting can induce significant cellular reprogramming. Comprehensive characterization of ovarian cancer cell-derived xenograft is therefore essential, as they represent a valuable translational platform for investigating therapy adapted ovarian cancer cells.

19 days ago

Journal

CDH2 (Cadherin 2) • SNAI2 (Snail Family Transcriptional Repressor 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • ALDH3A1 (Aldehyde Dehydrogenase 3 Family Member A1)

cisplatin

20d

Arginase 2 Promotes Colorectal Cancer Metastasis via PI3K/AKT Pathway Activation and Regulates Tumor Immune Infiltration. (PubMed, Cancer Med)

ARG2 is an independent prognostic marker for CRC. It promotes CRC progression via regulating EMT and PI3K/AKT, holding potential as a novel diagnostic and therapeutic target.

20 days ago

Journal

MMP2 (Matrix metallopeptidase 2) • CDH2 (Cadherin 2) • ARG2 (Arginase 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)

20d

Inhibition of TRAP1 in the C-terminal domain influences mitochondria properties and breast cancer cell metabolism. (PubMed, Biomed Pharmacother)

The differences between cell types need to be clarified. This study confirms that TRAP1 is a target of interest in breast cancer cells, but some of its functions still need to be elucidated.

20 days ago

Journal

ZEB1 (Zinc Finger E-box Binding Homeobox 1) • HSF1 (Heat Shock Transcription Factor 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)