Our findings highlight complex immune and autoimmune responses that contribute to ongoing inflammation and tissue damage post-SCI, underscoring new avenues for therapeutic interventions targeting these molecular processes.
9 months ago
Journal
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TNFA (Tumor Necrosis Factor-Alpha) • CD68 (CD68 Molecule) • FCGR2A (Fc fragment of IgG receptor IIa) • FCGR2B (Fc Fragment Of IgG Receptor IIb) • ZDHHC22 (Zinc Finger DHHC-Type Palmitoyltransferase 22)
Our results provide novel insights into the DEGs and factors affecting liver cancer immunotherapy. Meanwhile, CDCA7 was identified as a potential therapeutic target in this patient population.
almost 3 years ago
Journal • IO biomarker
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PRSS3 (Serine Protease 3) • IGFBP1 (Insulin Like Growth Factor Binding Protein 1) • POU2AF1 (POU Class 2 Homeobox Associating Factor 1) • ZDHHC22 (Zinc Finger DHHC-Type Palmitoyltransferase 22)
Targeting ZDHHCs also promoted the sensitivity of glioma cells to temozolomide (TMZ) chemotherapy...Taken together, our findings suggest that the inhibition of ZDHHCs suppresses glioma-cell viability and microglial infiltration. Targeting ZDHHCs may be promising for glioma treatments.