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    BIOMARKER:

    ZCCHC8-ROS1 fusion

    i
    Other names: ZCCHC8, Zinc Finger CCHC-Type Containing 8, Zinc Finger CCHC Domain-Containing Protein 8, TRAMP-Like Complex RNA-Binding Factor ZCCHC8, DKFZp434E2220, Zinc Finger, CCHC Domain Containing 8, PFBMFT5, ROS1, ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1, C-Ros Oncogene 1 Receptor Tyrosine Kinase, Proto-Oncogene Tyrosine-Protein Kinase ROS, Proto-Oncogene C-Ros-1, MCF3, ROS, V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian), ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, Transmembrane Tyrosine-Specific Protein Kinase, Receptor Tyrosine Kinase C-Ros Oncogene 1, C-Ros Receptor Tyrosine Kinase, Proto-oncogene C-Ros, C-Ros-1
    Entrez ID:
    6098; 55596
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over1year
    Modeling Spitz melanoma in zebrafish using sequential mutagenesis. (PubMed, Dis Model Mech)
    Subsequent electroporation with tissue-specific CRISPR, targeting only tp53 was sufficient to induce transformation to melanoma. Our model exhibits the use of sequential mutagenesis in the adult zebrafish, and demonstrates that ZCCHC8-ROS1 induces a spectrum of melanocytic lesions that closely mimics human Spitz neoplasms.
    Journal
    |
    TP53 (Tumor protein P53) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • ZCCHC8 (Zinc Finger CCHC-Type Containing 8)
    |
    ROS1 fusion • ZCCHC8-ROS1 fusion