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    GENE:

    ZC3H7A (Zinc Finger CCCH-Type Containing 7A)

    i
    Other names: ZC3H7A, Zinc Finger CCCH-Type Containing 7A, Zinc Finger CCCH Domain-Containing Protein 7A, Zinc Finger CCCH-Type Domain Containing 7, HSPC055, ZC3HDC7, ZC3H7, Zinc Finger CCCH-Type Containing 7, Zinc-Finger Protein AY163807
    7ms
    ZC3H7A/B::BCOR fusion fibromyxoid sarcoma of soft tissue: an emerging aggressive sarcoma overlapping with malignant ossifying fibromyxoid tumors. (PubMed, Virchows Arch)
    This series comprises seven additional ZC3H7A/B::BCOR soft tissue sarcomas associated with aggressive clinical outcomes. Whether this aggressive sarcoma represents a molecular subtype of malignant OFMT or a genetic variant of BCOR-rearranged sarcomas remains to be further verified.
    Journal
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    CCND1 (Cyclin D1) • BCOR (BCL6 Corepressor) • CD34 (CD34 molecule) • SOX10 (SRY-Box 10) • MUC4 (Mucin 4, Cell Surface Associated) • ZC3H7A (Zinc Finger CCCH-Type Containing 7A)
    over2years
    Rapid and Cost-Efficient Detection of RET Rearrangements in a Large Consecutive Series of Lung Carcinomas. (PubMed, Int J Mol Sci)
    RET-rearranged tumors obtained from females, but not males, had a decreased level of expression of thymidylate synthase (p < 0.00001), which is a known predictive marker of the efficacy of pemetrexed. The results of our study provide a viable alternative for RET testing in facilities that do not have access to NGS due to cost or technical limitations.
    Journal
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    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • RET (Ret Proto-Oncogene) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • TYMS (Thymidylate Synthetase) • ZC3H7A (Zinc Finger CCCH-Type Containing 7A)
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    RET fusion • RET rearrangement • RET expression • TYMS expression
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    pemetrexed