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ZBTB16 (Zinc Finger And BTB Domain Containing 16)

News alerts, weekly reports and conference planners

Intracellular bacteria modulate the immune microenvironment of oral squamous cell carcinoma. (PubMed, Cell Rep)

However, intracellular bacteria weaken the communication between cDC1 and these immune cells, potentially reducing therapeutic efficacy. Our study provides a foundation for further investigation into the mechanisms by which intracellular bacteria mediate effective responses to NICB in OSCC.

1 day ago

Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • GZMK (Granzyme K) • ZBTB16 (Zinc Finger And BTB Domain Containing 16)

PD-L1 expression

Transcriptomic and multi-layer variant analysis identifies STAT3 and HIF1A as central regulators of regulated cell death pathways in lung squamous cell carcinoma. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)

Current multi-omics analysis delineates STAT3 and HIF1A as central regulators coordinating apoptotic and necroptotic cross talk in LUSC. Deleterious nsSNPs within these TFs highlight structural vulnerabilities potentially driving tumor progression and therapeutic resistance, offering promising targets for precision-based intervention.

3 days ago

Journal

HIF1A (Hypoxia inducible factor 1, alpha subunit) • STAT3 (Signal Transducer And Activator Of Transcription 3) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • ZBTB16 (Zinc Finger And BTB Domain Containing 16)

Subtype-Specific m6A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer. (PubMed, Int J Mol Sci)

These findings uncover subtype-specific m6A circRNA methylation landscapes that may contribute to tumor aggressiveness and heterogeneity. Identified circRNAs represent candidates for investigation as biomarkers for subtype classification and prognosis and may inform future research into epigenetic and post-transcriptional therapeutic targets in breast cancer.

1 month ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • CDC42 (Cell Division Cycle 42) • ZBTB16 (Zinc Finger And BTB Domain Containing 16)

2ms

Atrazine Induces Reproductive Toxicity in an In Vitro Spermatogenesis (IVS) Model. (PubMed, Biomedicines)

ATZ exerts dose- and genotype-dependent effects on IVS through coordinated regulation of oxidative stress and apoptosis. These findings highlight the interplay between Nrf2-mediated antioxidant defenses, apoptotic signaling, and genetic background in shaping spermatogenic outcomes, providing mechanistic insight into ATZ-induced reproductive toxicity in a human-relevant in vitro spermatogenesis model.

2 months ago

Preclinical • Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • FASLG (Fas ligand) • SOX2 • CASP3 (Caspase 3) • POU5F1 (POU Class 5 Homeobox 1) • NQO1 (NAD(P)H dehydrogenase, quinone 1) • CASP9 (Caspase 9) • CDK1 (Cyclin-dependent kinase 1) • GFRA1 (GDNF Family Receptor Alpha 1) • ZBTB16 (Zinc Finger And BTB Domain Containing 16)

POU5F1 expression

3ms

Transcriptome biomarkers of colon cancer liver metastasis response to neoadjuvant triplet chemotherapy: a case series. (PubMed, J Circ Biomark)

The triplet FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) may be considered an effective option in the neoadjuvant setting for metastatic colon cancer (mCRC). Data obtained indicate transcriptional discordance between the primary tumors and liver metastases during neoadjuvant FOLFOXIRI, with the pattern of DEGs involved in their response being distinct. The EPS8L2 transcript could be regarded as a candidate biomarker of liver complete response; however, prognostic conclusions cannot be drawn from this cohort.

3 months ago

Journal

IL7R (Interleukin 7 Receptor) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • SERPINE1 (Serpin Family E Member 1) • IL1RN (Interleukin 1 receptor antagonist) • NAMPT (Nicotinamide Phosphoribosyltransferase) • PER1 (Period Circadian Clock 1) • TAGLN (Transgelin) • ZBTB16 (Zinc Finger And BTB Domain Containing 16) • ATF3 (Activating Transcription Factor 3) • CTGF (Connective tissue growth factor) • DUSP1 (Dual Specificity Phosphatase 1) • GADD45B (Growth Arrest And DNA Damage Inducible Beta) • ISG20 (Interferon Stimulated Exonuclease Gene 20) • TSC22D3 (TSC22 Domain Family Member 3)

5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium

5ms

IL-17-producing γδ T cells in the tumor microenvironment promote radioresistance in mice. (PubMed, J Clin Invest)

Mechanistically, radiotherapy-induced tumor cell-derived microparticles containing dsDNA activated the cGAS-STING/NF-κB signaling pathway in macrophages, upregulating the expression of the chemokine CCL20, which was critical for γδ T cell recruitment. Targeting γδ T cells and IL-17A enhanced radiosensitivity and improved the efficacy of radiotherapy combined with anti-PD-1 immunotherapy, providing potential therapeutic strategies to overcome radioresistance.

5 months ago

Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker

STING (stimulator of interferon response cGAMP interactor 1) • CCL20 (C-C Motif Chemokine Ligand 20) • IL17A (Interleukin 17A) • ZBTB16 (Zinc Finger And BTB Domain Containing 16)

5ms

Invariant TCR-triggered protein kinase D activation mediates NKT cell development. (PubMed, J Exp Med)

Mutant mice lacking the Ikaros-binding site (Zbtb16∆IBS) generated fewer iNKT cells than WT mice. These results suggest that PKD links iTCRs to PLZF induction through Ikaros, thereby mediating iNKT cell development.

5 months ago

Journal

IKZF1 (IKAROS Family Zinc Finger 1) • CD4 (CD4 Molecule) • ZBTB16 (Zinc Finger And BTB Domain Containing 16)

6ms

Genome-wide interaction study of physical activity and genetic susceptibility on colorectal cancer using UK biobank data. (PubMed, Sci Rep)

At the gene and pathway levels, RNASEL, NSD1, and efferocytosis showed nominal signals, although none reached statistical significance after correction. Although we could not find associations that met the significance threshold after adjusting for multiple testing, these preliminary findings help us to understand the interplay between genes and lifestyle in CRC.

6 months ago

Journal

NSD1 (Nuclear Receptor Binding SET Domain Protein 1) • ZBTB16 (Zinc Finger And BTB Domain Containing 16)

7ms

Pathogenic Genomic Alterations in Circulating Tumor DNA Predict Overall Survival in Men with Metastatic Castrate-resistant Prostate Cancer. (PubMed, Eur Urol)

Incorporation of PGAs from ctDNA into a CG model improved OS prediction by nearly 30% over a clinical model. This model can classify patients into risk groups and is useful for selecting patients in future mCRPC trials.

7 months ago

Journal • Circulating tumor DNA

BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • AR (Androgen receptor) • RB1 (RB Transcriptional Corepressor 1) • CCND1 (Cyclin D1) • MSH6 (MutS homolog 6) • FANCA (FA Complementation Group A) • ZFHX3 (Zinc Finger Homeobox 3) • CHD1 (Chromodomain Helicase DNA Binding Protein 1) • PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) • RSPO2 (R-Spondin 2) • ZBTB16 (Zinc Finger And BTB Domain Containing 16) • NKX3-1 (NK3 homeobox 1)

7ms

Exploring the zinc-binding proteins in the mutational hotspots of human cancer. (PubMed, J Trace Elem Med Biol)

The analysis of mutations in the Zn ion binding sites of the ZBPs revealed that mutations affect the proteins' structure, function, and binding affinity, potentially leading to cancer. Investigating mutations in the Zn binding sites of these proteins will pave the way for cancer treatments by enhancing our understanding of their role in cancer spread and invasion.

7 months ago

Journal

BCL6 (B-cell CLL/lymphoma 6) • WT1 (WT1 Transcription Factor) • RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase) • TRIM33 (Tripartite Motif Containing 33) • IKZF3 (IKAROS Family Zinc Finger 3) • MECOM (MDS1 And EVI1 Complex Locus) • BCL11B (BAF Chromatin Remodeling Complex Subunit BCL11B) • TRIM24 (Tripartite Motif Containing 24) • ZBTB16 (Zinc Finger And BTB Domain Containing 16) • PATZ1 (POZ/BTB And AT Hook Containing Zinc Finger 1) • ZNF501 (Zinc Finger Protein 501)

8ms

Determination of survival associated genetic biomarkers to discover novel therapeutic targets for acute myeloid leukaemia. (PubMed, J Chemother)

Drug repurposing using the LINCS L1000CDS2 database highlighted potential therapeutics, including 16-Hydroxytriptolide and Tryptosthin AG-1478, with roles in reversing hazardous gene expression patterns. Additional candidates such as Vemurafenib, Parthenolide and Wortmannin, demonstrated promise as targeted agents. These findings underscore the potential of integrating bioinformatics and drug discovery to identify precision medicine in AML. Further studies are warranted to validate these targets and explore their clinical utility.

8 months ago

Journal

ZBTB16 (Zinc Finger And BTB Domain Containing 16)

Zelboraf (vemurafenib) • AG1478