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GENE:

YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

News alerts, weekly reports and conference planners

2ms

Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer. (PubMed, Front Bioinform)

The results emphasizes that EGCG has strong binding affinity towards YWHAZ, revealing that miR-30a-EGCG targets TNBC synergistically through cell-cycle-mediated pathways. The findings give rational support for miRNA-guided phytochemical-based TNBC therapeutic development.

2 months ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • PGR (Progesterone receptor) • PCNA (Proliferating cell nuclear antigen) • RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • ANLN (Anillin Actin Binding Protein) • CCNA1 (Cyclin A1) • MIR30A (MicroRNA 30a) • SKP2 (S-phase kinase-associated protein 2) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

HER-2 expression

3ms

Molecular Resonance Quantification and Label-Free Interactome Characterization of Total Proteome of Tumor Specimens Decipher Responder and Success Predictors in Colorectal Cancer Patients Treated With Panitumumab. (PubMed, Cancer Med)

Combination of PIMS and NPOT coupled to label-free quantitative proteomics point towards the distinct panitumumab mode of action in CRC patients and highlights specific proteins as prognostic biomarkers which need further validation in a bigger cohort and multicentric investigation, ideally involving patient registry follow up data.

3 months ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • POLD1 (DNA Polymerase Delta 1) • PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) • ENO1 (Enolase 1) • YBX1 (Y-Box Binding Protein 1) • CTNND1 (Catenin Delta 1) • ITGB2 (Integrin Subunit Beta 2) • LRIG1 (Leucine Rich Repeats And Immunoglobulin Like Domains 1) • NT5C (5', 3'-Nucleotidase, Cytosolic) • PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • ITGB1 (Integrin Subunit Beta 1) • PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent 1G) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) • NCAPD2 (Non-SMC Condensin I Complex Subunit D2)

Vectibix (panitumumab)

3ms

Selection of reference genes and proteins for expression studies in pediatric gliomas. (PubMed, Discov Oncol)

Overall, the results show that the expression of reference genes in pediatric gliomas differs from what has been reported for adult gliomas. This research provides valuable insights into the molecular characteristics of pediatric gliomas and may have important implications for diagnosis and treatment.

3 months ago

Journal

GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

4ms

Nanomaterial-assisted immunodiagnostic profiling and therapeutic targeting of hepatocellular carcinoma: from molecular biomarkers to clinical applications. (PubMed, Front Immunol)

By integrating transcriptomic and proteomic screening with epitope-level validation, we identified a novel panel of immunogenic biomarkers suitable for nanomaterial-enabled diagnostics in HCC. These findings support the translational potential of peptide-nano scaffold conjugates in developing minimally invasive, immune-responsive biosensing and therapeutic tools tailored for early-stage liver cancer management.

4 months ago

Journal

HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) • ADH4 (Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide)

5ms

Exosome-like nanovesicles from Dunaliella salina efficient sequential Co-delivery of anti-PDL1 and miR-375 for enhancing gene/immune therapy. (PubMed, Noncoding RNA Res)

In vivo results showed that cRGD-DENV-aPDL1/miR375 significantly inhibited tumor growth and affected the proliferation, migration and invasion of esophageal cancer cells by regulating YWHAZ. The potential of Dunaliella salina exosome-like nanovesicle carrier delivery system in cancer therapy and can provide a very promising platform for the rapid and large-scale generation of functionalized exosome-like nanovesicles.

5 months ago

Journal

MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • MIR375 (MicroRNA 375) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

5ms

Inhibiting Cyclin-Dependent Kinase 13-Mediated Nuclear Ubiquitous Casein Kinase and Cyclin-Dependent Kinase Substrate 1 Phosphorylation Facilitates Oxidative Stress-Induced Apoptosis in Melanoma. (PubMed, Mol Carcinog)

Furthermore, we found that p-NUCKS1 was highly expressed in tumor specimens from melanoma patients, and silencing of NUCKS1 inhibited tumor growth in melanoma A375 and A875-bearing mouse models. Therefore, p-NUCKS1 could act as a potential target for melanoma treatment by mediating oxidative stress-induced apoptosis.

5 months ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • CHEK2 (Checkpoint kinase 2) • CDC25C (Cell Division Cycle 25C) • CDK13 (Cyclin Dependent Kinase 13) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

7ms

Aloin protects against UVB-induced apoptosis by modulating integrated signaling pathways. (PubMed, Front Pharmacol)

Aloin upregulated proteins associated with cell cycle regulation and antioxidant responses, such as CCND3, GSTM4, GNA12, SKIL, YWHAZ, and PKN3 while downregulating pro-apoptotic protein FOXO3. These findings highlight aloin's potential as a therapeutic agent for UVB-induced skin damage by effectively modulating cellular stress responses.

7 months ago

Journal

CCND3 (Cyclin D3) • TGFB1 (Transforming Growth Factor Beta 1) • GNA12 (G Protein Subunit Alpha 12) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

8ms

Circ0515 reprogramming mitochondrial succinate metabolism and promotes lung adenocarcinoma progression through regulating SDHB. (PubMed, Cell Death Dis)

On the other hand, circ0515 recruited RNA binding motif protein 45 (RBM45) to stabilize SDHB mRNA, promoting SDHB expression and mitochondrial oxidative phosphorylation and succinate metabolism, leading to increased cisplatin resistance in lung cancer cells. These findings not only advance our understanding of the functional roles of circ0515 in lung cancer but also provide a theoretical basis for considering circ0515 as a potential therapeutic target for NSCLC.

8 months ago

Journal

SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) • RBM4 (RNA Binding Motif Protein 4) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

cisplatin

8ms

CYP8B1 is a prognostic biomarker with important functional implications in hepatocellular carcinoma. (PubMed, Oncol Rep)

Furthermore, the pro‑apoptotic protein Bax was upregulated, while the anti‑apoptotic protein Bcl‑2 was downregulated. In conclusion, CYP8B1 holds promise as a potential prognostic target for HCC.

8 months ago

Journal

BCL2 (B-cell CLL/lymphoma 2) • CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1) • CYP8B1 (Cytochrome P450 Family 8 Subfamily B Member 1) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

9ms

Selection and validation of reference genes for RT-qPCR normalization in dormant cancer cells. (PubMed, Sci Rep)

To prevent incorrect selection of a reference gene in dormant tumor cells, we analyzed the expression stability of the widely used housekeeping genes GAPDH, ACTB, TUBA1A, RPS23, RPS18, RPL13A, PGK1, EIF2B1, TBP, CYC1, B2M, and YWHAZ in the T98G, A549, and PA-1 cancer cell lines treated with the dual mTOR inhibitor AZD8055...The optimal reference genes among the 12 candidate reference genes were not revealed in the PA-1 cell line. Validation of the stability of the 12 investigated genes demonstrated that the incorrect selection of a reference gene resulted in a significant distortion of the gene expression profile in dormant cancer cells.

9 months ago

Journal

B2M (Beta-2-microglobulin) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • EIF2B4 (Eukaryotic Translation Initiation Factor 2B Subunit Delta) • PGK1 (Phosphoglycerate Kinase 1) • RPL13A (Ribosomal Protein L13a) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

AZD8055

9ms

Spartin Promotes Smurf1-Mediated Ubiquitination Modification of YWHAZ to Inhibit Cisplatin Resistance in Ovarian Cancer. (PubMed, FASEB J)

In conclusion, Spartin-induced Smurf1-mediated ubiquitination modification of YWHAZ to inactivate autophagy, thereby increasing the sensitivity of OV cells to DDP. Our findings suggest that Spartin-combined therapy might act as an effective approach to fight against DDP resistance in OV.

9 months ago

Journal

LAMP2 (Lysosomal Associated Membrane Protein 2) • SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

cisplatin

12ms

A novel glycolysis-related gene signature for predicting prognosis and immunotherapy efficacy in breast cancer. (PubMed, Front Immunol)

The AUC values for this combined prediction model were 0.827 (1-year OS), 0.792 (3-year OS), and 0.783 (5-year OS), indicating an outstanding predictive performance. A new GRPGs based prediction model was built to predict the OS and immunotherapeutic response of patients with BC.

12 months ago

Journal • Tumor mutational burden • Gene Signature • BRCA Biomarker • IO biomarker

TMB (Tumor Mutational Burden) • BRCA (Breast cancer early onset) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • PGK1 (Phosphoglycerate Kinase 1) • PTK2 (Protein Tyrosine Kinase 2) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) • VDAC1 (Voltage Dependent Anion Channel 1)