^
    4d
    Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initiated trial. (PubMed, J Immunother Cancer)
    The study shows that YSCH-01 injections were safe and well tolerated and exhibited preliminary efficacy in patients with advanced solid tumors, supporting further investigation to evaluate its efficacy and safety.
    Journal • Metastases
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6)
    |
    YSCH-01
    7ms
    Double-modified oncolytic adenovirus armed with a recombinant interferon-like gene enhanced abscopal effects against malignant glioma. (PubMed, Neurooncol Adv)
    Furthermore, we employed a patient-derived xenograft model of recurrent glioblastoma to test the effectiveness of YSCH-01 against temozolomide. Our initial findings confirm that a double-modified oncolytic adenovirus armed with a recombinant interferon-like gene is both safe and effective in the treatment of malignant glioma. Furthermore, when utilized in combination with a targeted therapy gene strategy, these oAds exhibit a more profound effect in tumor therapy and an enhanced ability to inhibit tumor growth at remote sites.
    Journal • Oncolytic virus
    |
    BIRC5 (Baculoviral IAP repeat containing 5)
    |
    temozolomide • YSCH-01
    11ms
    YSCH-01: Safety and Tolerability Study of Recombinant L-IFN Adenovirus Injection in Patients With Recurrent Glioblastoma (clinicaltrials.gov)
    P1, N=6, Recruiting, Binhai Hospital of Fujian Medical University | Not yet recruiting --> Recruiting
    Enrollment open
    |
    YSCH-01
    11ms
    YSCH-01: Safety and Tolerability Study of Recombinant L-IFN Adenovirus Injection in Patients With Recurrent Glioblastoma (clinicaltrials.gov)
    P1, N=6, Not yet recruiting, Binhai Hospital of Fujian Medical University
    New P1 trial
    |
    YSCH-01