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    BIOMARKER:

    YBX1 rs10493112

    i
    Other names: YBX1, Y-Box Binding Protein 1, CCAAT-Binding Transcription Factor I Subunit A, Enhancer Factor I Subunit A, Y-Box Transcription Factor, DNA-Binding Protein B, NSEP1, YB-1, Major Histocompatibility Complex, Class II, Y Box-Binding Protein I, Nuclease Sensitive Element Binding Protein 1, MDR-NF1, NSEP-1, CSDA2
    Entrez ID:
    4904
    Related biomarkers:
    Expression
    2ms
    Connecting Gene Variation to Treatment Outcomes in Metastatic Castration-Resistant Prostate Adenocarcinoma: Insights into Second-Generation Androgen Receptor Axis-Targeted Therapies. (PubMed, Int J Mol Sci)
    Second-generation androgen receptor axis-targeted (ARAT) agents, namely abiraterone acetate (AbA) and enzalutamide (ENZ), are currently used in the management of metastatic castration-resistant PC (mCRPC). In the same subgroup, significant associations of HSD3B1 rs1047303 (CC/CA vs. AA; HR = 3.41; p = 0.025), YBX1 rs12030724 (AT vs. AA; HR = 3.54; p = 0.039) and YBX1 rs10493112 (log-rank test, p = 0.041; CC vs. AA/AC; HR = 3.22; p = 0.053) with overall survival were also observed, which were confirmed by multivariate Cox analyses. Although validation with larger cohorts is required, these findings suggest that SNPs could enhance the prognosis assessment of mCRPC patients, leading to a more personalised treatment.
    Journal • Metastases
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    CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • YBX1 (Y-Box Binding Protein 1) • HSD3B1 (Hydroxy-Delta-5-Steroid Dehydrogenase 3 Beta- And Steroid Delta-Isomerase 1)
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    YBX1 rs10493112
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    Xtandi (enzalutamide capsule) • abiraterone acetate