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    BIOMARKER:

    YAP1 underexpression

    i
    Other names: YAP2, YAP, Yes-Associated Protein 2, Yorkie Homolog, COB1, Protein Yorkie Homolog, YAP65, Yes-Associated Protein 1, Transcriptional Coactivator YAP1, YAP1, Yes associated protein 1, Yes-Associated Protein YAP65 Homolog
    Entrez ID:
    10413
    Related biomarkers:
    Expression
    Others
    11ms
    YAP1 expression in colorectal cancer confers the aggressive phenotypes via its target genes. (PubMed, Cell Cycle)
    YAP1 over-expression in CRC cells enhanced their migration and invasion significantly which can be reversed by AXL, CTGF, or CYR61 interference. The study suggested that YAP1 affected the prognosis of CRC patients and controlled the abilities of invasion and migration of CRC cells via its target genes AXL, CTGF, and CYR61.
    Journal
    |
    AXL (AXL Receptor Tyrosine Kinase) • YAP1 (Yes associated protein 1) • CCN1 (Cellular Communication Network Factor 1) • CTGF (Connective tissue growth factor)
    |
    YAP1 overexpression • YAP1 underexpression
    over2years
    Clinical and pathological impact of neuroendocrine lineage-specific transcription factors in adenocarcinoma of the colon. (EACR 2022)
    None of the genes was correlated with any specific genotype. Conclusion Our data show that: i) ADC-NED are associated with specific profiles of transcriptional regulation; ii) the expression of these genes is influenced by the tumor genotype; iii) the association of some of these genes with clinical and pathological features support their potential role as novel biomarkers.
    Clinical
    |
    BRAF (B-raf proto-oncogene) • NOTCH1 (Notch 1) • DLL3 (Delta Like Canonical Notch Ligand 3) • YAP1 (Yes associated protein 1) • MYCL (MYCL Proto-Oncogene BHLH Transcription Factor) • POU2F3 (POU Class 2 Homeobox 3) • SYP (Synaptophysin) • ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) • NEUROD1 (Neuronal Differentiation 1)
    |
    BRAF mutation • NOTCH1 expression • YAP1 underexpression • POU2F3 expression • NOTCH1 overexpression