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DRUG:

XRD-0394

i
Other names: XRD-0394
Associations
Trials
Company:
XRad Therap
Drug class:
DNA PK inhibitor, ATM kinase inhibitor
Associations
Trials
1m
A novel dual ATM/DNA-PK inhibitor, XRD-0394, potently radiosensitizes and potentiates PARP and topoisomerase I inhibitors. (PubMed, Mol Cancer Ther)
A Phase Ia clinical trial (NCT05002140) with XRD-0394 in combination with RT has completed. These results provide a rationale for future clinical trials with XRD-0394 in combination with RT, PARP inhibitors and targeted delivery of topoisomerase I inhibitors.
Journal
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BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
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XRD-0394
4ms
Trial of XRD-0394, a Kinase Inhibitor, in Combination With Palliative Radiotherapy in Advanced Cancer Patients (clinicaltrials.gov)
P1, N=12, Completed, XRad Therapeutics Inc | Active, not recruiting --> Completed | Trial completion date: Dec 2023 --> Jul 2023 | Trial primary completion date: Dec 2023 --> Jul 2023
Trial completion • Trial completion date • Trial primary completion date • Combination therapy • Metastases
|
XRD-0394
10ms
Trial of XRD-0394, a Kinase Inhibitor, in Combination With Palliative Radiotherapy in Advanced Cancer Patients (clinicaltrials.gov)
P1, N=11, Active, not recruiting, XRad Therapeutics Inc | Recruiting --> Active, not recruiting | N=38 --> 11
Enrollment closed • Enrollment change • Combination therapy • Metastases
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XRD-0394