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GENE:

XRCC3 (X-Ray Repair Cross Complementing 3)

News alerts, weekly reports and conference planners

BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments. (PubMed, Nature)

These distinct assemblies are differentially regulated by ATPase activity, defining a dynamic BCDX2-CX3 "loader" and a stable DX2-CX3 "anchor" that provide functional modularity to the HR machinery. This work provides a unifying mechanism for human RAD51 paralog function and delivers an atomic blueprint for interpreting disease-causing mutations.

1 month ago

Journal

RAD51 (RAD51 Homolog A) • RAD51B (RAD51 Paralog B) • RAD51C (RAD51 paralog C) • RAD51D (RAD51 paralog D) • XRCC2 (X-Ray Repair Cross Complementing 2) • XRCC3 (X-Ray Repair Cross Complementing 3)

2ms

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity. (PubMed, Sci Adv)

The CX3 complex-mediated R-loop resolution is independent of its fork maintenance function. Collectively, we demonstrate a previously unidentified role of the CX3 complex in preventing R-loop-induced genome instability by regulating FANCM-mediated R-loop resolution.

2 months ago

Journal

RAD51 (RAD51 Homolog A) • RAD51C (RAD51 paralog C) • FANCM (FA Complementation Group M) • XRCC3 (X-Ray Repair Cross Complementing 3)

3ms

Niraparib in Tumors Metastatic to the CNS (clinicaltrials.gov)

P2, N=20, Active, not recruiting, Massachusetts General Hospital | Trial primary completion date: Dec 2025 --> Dec 2026

3 months ago

Trial primary completion date

BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • HRD (Homologous Recombination Deficiency) • BAP1 (BRCA1 Associated Protein 1) • RAD51B (RAD51 Paralog B) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • RAD51C (RAD51 paralog C) • RAD50 (RAD50 Double Strand Break Repair Protein) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • BARD1 (BRCA1 Associated RING Domain 1) • NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)) • RAD54L (DNA Repair And Recombination Protein RAD54) • XRCC2 (X-Ray Repair Cross Complementing 2) • RAD54B (RAD54 Homolog B) • XRCC3 (X-Ray Repair Cross Complementing 3)

HRD • ATM mutation • PALB2 mutation • BRIP1 mutation • RAD51C mutation • RAD51D mutation • RAD51B mutation • BARD1 mutation • RAD54L mutation

Zejula (niraparib)

3ms

Integrated case-control and in silico analysis of DNA double-strand break repair gene variants (RAD51, XRCC2, XRCC3, XRCC4, and LIG4) for ovarian cancer susceptibility. (PubMed, Gene)

Overall, RAD51 and LIG4 polymorphisms may contribute to OC susceptibility in South Indian women. Larger, multi-center studies are warranted to validate these findings and explore their potential as predictive biomarkers for OC.

3 months ago

Journal

HRD (Homologous Recombination Deficiency) • RAD51 (RAD51 Homolog A) • XRCC2 (X-Ray Repair Cross Complementing 2) • XRCC3 (X-Ray Repair Cross Complementing 3)

3ms

Single Nucleotide Polymorphisms as Biomarkers of Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer: A Systematic Review. (PubMed, Cancers (Basel))

Although XRCC1 and MTHFR polymorphisms have been extensively studied, their predictive utility remains inconclusive. Future research should prioritize large, multicenter prospective studies with standardized treatment and outcome definitions, and consider polygenic risk models or integrated multi-omic approaches.

3 months ago

Review • Journal

ERCC1 (Excision repair cross-complementation group 1) • ERCC2 (Excision repair cross-complementation group 2) • TYMS (Thymidylate Synthetase) • MTHFR (Methylenetetrahydrofolate Reductase) • XRCC1 (X-Ray Repair Cross Complementing 1) • XRCC3 (X-Ray Repair Cross Complementing 3)

5ms

Cryo-electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2. (PubMed, Science)

The RAD51B complex promotes dynamic adenosine triphosphate hydrolysis-dependent assembly of RAD51 filaments, whereas the XRCC3 complex stably caps the 5'-termini of RAD51 filaments to promote homologous pairing, as visualized by cryo-electron microscopy. Highly conserved across evolution, these complexes reveal insights into RAD51 filament formation and capping during DNA repair and replication fork stabilization.

5 months ago

Journal

HRD (Homologous Recombination Deficiency) • RAD51 (RAD51 Homolog A) • RAD51B (RAD51 Paralog B) • RAD51C (RAD51 paralog C) • RAD51D (RAD51 paralog D) • XRCC2 (X-Ray Repair Cross Complementing 2) • XRCC3 (X-Ray Repair Cross Complementing 3)

6ms

A comprehensive compilation of data on the association between XRCC3 polymorphisms and thyroid cancer susceptibility. (PubMed, BMC Endocr Disord)

XRCC3 rs1799794 polymorphism is associated with increased thyroid cancer risk, particularly under recessive genetic models. The rs1799796 variant may confer a protective effect in Asian populations, whereas rs861539 shows no significant association. These results highlight population-specific genetic effects and underscore the importance of considering ethnicity in genetic association studies. Further large, well-designed investigations are warranted to confirm these findings and to explore potential gene-environment interactions.

6 months ago

Clinical • Journal

HRD (Homologous Recombination Deficiency) • XRCC3 (X-Ray Repair Cross Complementing 3)

7ms

Genomic characterization of patients with colorectal cancer. (PubMed, Hered Cancer Clin Pract)

These findings highlight the utility of NGS in identifying germline variants linked to hereditary CRC syndromes and emphasize the need for functional studies to assess the pathogenicity of VUS.

7 months ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • NF1 (Neurofibromin 1) • FGFR (Fibroblast Growth Factor Receptor) • PALB2 (Partner and localizer of BRCA2) • MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • PMS2 (PMS1 protein homolog 2) • CHEK2 (Checkpoint kinase 2) • RAD51D (RAD51 paralog D) • MUTYH (MutY homolog) • SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1) • ABRAXAS1 (Abraxas 1 BRCA1 A Complex Subunit 2) • FANCC (FA Complementation Group C) • XRCC3 (X-Ray Repair Cross Complementing 3)

7ms

Genetic Variants Associated with Breast Cancer Are Detected by Whole-Exome Sequencing in Vietnamese Patients. (PubMed, Diagnostics (Basel))

This is the first WES study to identify BC-associated genetic variants in Vietnamese patients, providing a comprehensive database of BC susceptibility gene variants. We suggest using WES as a tool to identify genetic variants in BC patients for risk prediction and treatment guidance.

7 months ago

Journal

ER (Estrogen receptor) • TP53 (Tumor protein P53) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • FGFR2 (Fibroblast growth factor receptor 2) • NF1 (Neurofibromin 1) • MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • PMS2 (PMS1 protein homolog 2) • MSH3 (MutS Homolog 3) • BARD1 (BRCA1 Associated RING Domain 1) • RAD54L (DNA Repair And Recombination Protein RAD54) • CASP8 (Caspase 8) • WRN (WRN RecQ Like Helicase) • CHD8 (Chromodomain Helicase DNA Binding Protein 8) • RECQL (RecQ Like Helicase) • KLLN (Killin P53 Regulated DNA Replication Inhibitor) • LZTR1 (Leucine Zipper Like Transcription Regulator 1) • RB1CC1 (RB1 Inducible Coiled-Coil 1) • SLX4 (SLX4 Structure-Specific Endonuclease Subunit) • XRCC3 (X-Ray Repair Cross Complementing 3) • ACVR1B (Activin A Receptor Type 1B)

7ms

Niraparib in Tumors Metastatic to the CNS (clinicaltrials.gov)

P2, N=20, Active, not recruiting, Massachusetts General Hospital | Recruiting --> Active, not recruiting

7 months ago

Enrollment closed

HRD • ATM mutation • PALB2 mutation • BRIP1 mutation • RAD51C mutation • RAD51D mutation • RAD51B mutation • BARD1 mutation • RAD54L mutation

Zejula (niraparib)

7ms

Expression analysis of C-FOS and XRCC3 Thr241Met polymorphism in gastric cancer. (PubMed, Cell Mol Biol (Noisy-le-grand))

We present in our findings that molecular profiling coupled with demographic profiling is highly relevant in risk assessment and early detection techniques in gastric cancer. The study contributes to the further comprehension of the molecular pathogenesis of gastric carcinogenesis and suggests C-FOS and XRCC3 as possible clinical and epidemiological markers.

7 months ago

Journal

FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2) • XRCC3 (X-Ray Repair Cross Complementing 3)

8ms

Development of a predictive model for neutropenia risk in Japanese breast cancer patients treated with doxorubicin and cyclophosphamide. (PubMed, Br J Clin Pharmacol)

CIN was linked to improved survival in breast cancer patients. The predictive model including genetic factors provided a more accurate assessment of CIN risk, potentially enabling more personalized treatment approaches.

8 months ago

Journal

ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ERCC1 (Excision repair cross-complementation group 1) • ERCC2 (Excision repair cross-complementation group 2) • XRCC3 (X-Ray Repair Cross Complementing 3)

doxorubicin hydrochloride • cyclophosphamide