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    GENE:

    XPNPEP1 (X-Prolyl Aminopeptidase 1)

    i
    Other names: X-Prolyl Aminopeptidase 1, Xaa-Pro Aminopeptidase 1, X-Prolyl Aminopeptidase (Aminopeptidase P) 1, Soluble, X-Prolyl Aminopeptidase 1, Soluble, Aminoacylproline Aminopeptidase, Cytosolic Aminopeptidase P, Soluble Aminopeptidase P, X-Pro Aminopeptidase 1, XPNPEPL1, XPNPEPL, X-Prolyl Aminopeptidase (Aminopeptidase P)-Like, Aminopeptidase P, Cytosolic, XPNPEP1, XPNPEP, APP1, SAMP, SAmp
    11ms
    Sex hormones, blood metabolites and proteins mediating the causal associations between gut microbiota and prostatic diseases: evidences from Mendelian randomization study. (PubMed, Prostate Int)
    In the mediation analysis, we identified 53 mediators linking the gut microbiota to prostatic diseases, with a specific emphasis on the critical roles played by sex hormones and blood metabolites, and identified 34 proteins that may be used as therapeutic targets, especially FGFR1 and XPNPEP1. Our study represents the first comprehensive exploration of the causal effects of the gut microbiota on prostatic diseases and reveals the mediating effects of sex hormones and blood metabolites on the "gut-prostate axis."
    Journal
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    FGFR1 (Fibroblast growth factor receptor 1) • XPNPEP1 (X-Prolyl Aminopeptidase 1)
    over2years
    The hypoxia-associated genes in immune infiltration and treatment options of lung adenocarcinoma. (PubMed, PeerJ)
    PDK3 and PFKL were protective factors in LUAD patients. This study demonstrates the effect of hypoxia-associated genes on immune infiltration in LUAD and provides options for immunotherapy and therapeutic strategies in LUAD.
    Journal • IO biomarker
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    XPNPEP1 (X-Prolyl Aminopeptidase 1) • PFKL (Phosphofructokinase, Liver Type) • SLC2A1 (Solute Carrier Family 2 Member 1) • STC1 (Stanniocalcin 1)
    over3years
    Proteomic Analyses Identified Novel Cyst Fluid Biomarkers in Differentiating Pancreatic Cystic Neoplasms (APA-Pancreatic 2022)
    Significant differences in cyst fluid between mucinous versus non-mucinous PCN, as well as inv-IPMN versus LG-IPMN were revealed by proteomic analysis. These differentially expressed proteins hold great potential as novel cyst fluid biomarkers for the management of PCN.
    EPCAM (Epithelial cell adhesion molecule) • CXCL5 (Chemokine (C-X-C motif) ligand 5) • XPNPEP1 (X-Prolyl Aminopeptidase 1)