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    BIOMARKER:

    XPA overexpression

    i
    Other names: XPAC, Xeroderma Pigmentosum Group A-Complementing Protein, Xeroderma Pigmentosum, Complementation Group A, DNA Repair Protein Complementing XP-A Cells, XP1
    Entrez ID:
    7507
    Related biomarkers:
    Expression
    11ms
    Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. (PubMed, ChemMedChem)
    The DNA excision repair protein ERCC1 and the DNA damage sensor protein, XPA are highly overexpressed in patient samples of cisplatin-resistant solid tumors including lung, bladder, ovarian, and testicular cancer...Furthermore, chemical shift perturbation mapping by NMR confirms that 1 binds within the same site as the truncated XPA67-80 peptide. These novel ERCC1 antagonists are useful chemical biology tools for investigating DNA damage repair pathways and provide a good starting point for medicinal chemistry optimization as therapeutics for sensitizing tumors to DNA damaging agents and overcoming resistance to platinum-based chemotherapy.
    Journal
    |
    ERCC1 (Excision repair cross-complementation group 1) • XPA (XPA, DNA Damage Recognition And Repair Factor)
    |
    XPA overexpression
    |
    cisplatin
    over3years
    XPA serves as an autophagy and apoptosis inducer by suppressing hepatocellular carcinoma in a PI3K/Akt/mTOR dependent manner. (PubMed, J Gastrointest Oncol)
    XPA overexpression was found to suppress HCC by inducing autophagy and apoptosis and repressing EMT and proliferation. Each of these effects may be involved in modulating the PI3K/Akt/mTOR signaling pathway.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • VIM (Vimentin) • XPA (XPA, DNA Damage Recognition And Repair Factor) • BECN1 (Beclin 1)
    |
    BCL2 expression • BAX expression • VIM expression • XPA expression • XPA overexpression