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    DRUG:

    XNW9015

    i
    Other names: XNW9015
    Associations

    News

    Trials
    Company:
    Evopoint
    Drug class:
    CDK7 inhibitor
    Related drugs:
    Associations

    News

    Trials
    almost2years
    Discovery of XNW9015, a potent, selective, and CNS-penetrating covalent inhibitor of CDK7 with excellent in vivo antitumor activities (AACR 2023)
    In the Palbociclib-resistant breast cancer cell line MCF-7, XNW9015 exhibited antiproliferative activity, with an IC50 of 81nM, while neither Palbociclib nor Fulvestrant can inhibit the cell viability...XNW9015 exhibited superior rodent pharmacokinetic characteristics when compared to LY3405105 (Eli Lilly and Company, WO2019099298)...In summary, XNW9015 has demonstrated potent in vitro and in vivo antitumor effects, favorable pharmacokinetic and toxicological properties. XNW9015 has become a potential clinical candidate for cancer therapeutics, both as monotherapies and in combination settings.
    Preclinical
    |
    CDK12 (Cyclin dependent kinase 12) • CDK2 (Cyclin-dependent kinase 2) • CDK7 (Cyclin Dependent Kinase 7) • CDK9 (Cyclin Dependent Kinase 9) • CDK1 (Cyclin-dependent kinase 1)
    |
    Ibrance (palbociclib) • fulvestrant • LY3405105 • XNW9015