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    GENE:

    XBP1 (X-box-binding protein 1)

    i
    Other names: XBP1, X-box-binding protein 1, Tax-responsive element-binding protein 5, TREB-5, XBP2
    15d
    XBP1-driven proliferative B cell subcluster in Diffuse Large B Cell Lymphoma linked to altered nucleotide metabolism. (PubMed, Eur J Med Res)
    This analysis has identified and characterized the proliferation-related B cells in DLBCL, which may provide some ideas for the treatment strategies in immune-oncology and cellular therapies.
    Journal
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    CD8 (cluster of differentiation 8) • CD74 (CD74 Molecule) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • XBP1 (X-box-binding protein 1)
    22d
    Potential involvement of the endoplasmic reticulum stress response in the development of cisplatin-induced muscle atrophy. (PubMed, J Toxicol Sci)
    This study examined the effects of five anticancer agents-cisplatin, 5-fluorouracil, vincristine, irinotecan, and cyclophosphamide-on mouse skeletal muscle. Targeting ER stress may help prevent chemotherapy-induced muscle wasting. Further studies are needed to clarify mechanisms and develop protective strategies.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • IGF1 (Insulin-like growth factor 1) • ATF4 (Activating Transcription Factor 4) • DDIT3 (DNA-damage-inducible transcript 3) • IL1B (Interleukin 1, beta) • XBP1 (X-box-binding protein 1) • FBXO32 (F-Box Protein 32)
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    cisplatin • 5-fluorouracil • cyclophosphamide • irinotecan • vincristine
    1m
    The critical role of GRP78/BiP MARylation in ER stress of KRAS-mutant colorectal cancer. (PubMed, JCI Insight)
    We also conducted a preliminary study on the specific site of function. Clarifying this molecular mechanism can provide a experimental basis for identifying effective targets for the intervention of KRAS-mutant CRC.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ATF4 (Activating Transcription Factor 4) • XBP1 (X-box-binding protein 1)
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    KRAS mutation
    1m
    STXBP1-E: Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy (clinicaltrials.gov)
    P1, N=50, Active, not recruiting, Weill Medical College of Cornell University | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
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    XBP1 (X-box-binding protein 1)
    1m
    Autophagy targeted nano-medicine in norphytane atrophic arthritis model: Beclin1/XBP/PTEN/STAT-3A genetic profile. (PubMed, Future Sci OA)
    Moreover, rheumatoid factor biomarkers including Cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP-9), tumor necrosis factor (TNF-α). Liposomal-Isethione significantly targeted MAut signaling pathways, including Beclin-1/XBP/COMP/STAT-3A/PI3K/AKT/PTEN via increased bioavailability and targeting inflamed tissues, thus decreased drug resistance.
    Journal
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    PTEN (Phosphatase and tensin homolog) • TNFA (Tumor Necrosis Factor-Alpha) • STAT3 (Signal Transducer And Activator Of Transcription 3) • MMP9 (Matrix metallopeptidase 9) • XBP1 (X-box-binding protein 1) • BECN1 (Beclin 1)
    1m
    Necrotic Cells Alter IRE1α-XBP1 Signaling and Induce Transcriptional Changes in Glioblastoma. (PubMed, Int J Mol Sci)
    Transcriptomic analysis and quantitative reverse transcription PCR (qRT-PCR) revealed that necrotic cell-induced XBP1u was associated with altered expression of XBP1-related genes, while XBP1 knockdown produced similar transcriptional changes and enhanced the effects of necrotic cell treatment. These findings suggest that necrotic cells impair canonical IRE1α-XBP1 signaling and induce transcriptional reprogramming in glioblastoma cells, which may contribute to tumor progression.
    Journal
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    ATF6 (Activating Transcription Factor 6) • NFKBIA (NFKB Inhibitor Alpha 2) • XBP1 (X-box-binding protein 1)
    2ms
    Tumor Necrosis Factor α-Induced Endoplasmic Reticulum Stress Promotes Airway Smooth Muscle Cell Proliferation. (PubMed, Am J Physiol Lung Cell Mol Physiol)
    Nuclear localization of Cyclin B1 increased significantly in TNFα treated hASM cells consistent with the formation of Cyclin B1/CDKs complexes, and increased cell proliferation. Inhibition of pIRE1αS724/XBP1s pathway mitigated TNFα induced Cyclin B1 and CDKs expression and hASM cell proliferation.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CDK1 (Cyclin-dependent kinase 1) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) • XBP1 (X-box-binding protein 1) • CCNB1 (Cyclin B1)
    2ms
    B-Cell Receptor-Associated Protein 31 Deficiency Aggravates Ethanol-Induced Liver Steatosis and Liver Injury via Attenuating Fatty Acid Oxidation and Glycogen Synthesis. (PubMed, Int J Mol Sci)
    Consistently, BAP31 knockdown amplified ethanol-induced lipid accumulation, inflammation, impaired glycogen storage, ER stress, and suppression of Pparα signaling in HepG2 cells. Together, these findings demonstrate that BAP31 deficiency exacerbates ethanol-induced liver steatosis, inflammation, and liver injury by impairing fatty acid oxidation and glycogen synthesis, and by amplifying ER stress responses.
    Journal
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    BAP1 (BRCA1 Associated Protein 1) • CD36 (thrombospondin receptor) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • XBP1 (X-box-binding protein 1) • ACOX1 (Acyl-CoA Oxidase 1) • PPARA (Peroxisome Proliferator Activated Receptor Alpha)
    2ms
    TRAF6 mediates vascular remodeling via endoplasmic reticulum stress-mitophagy in hypoxic pulmonary hypertension. (PubMed, Free Radic Biol Med)
    Our findings demonstrate that TRAF6 exacerbates endoplasmic reticulum stress and dysregulates mitophagy, thereby driving pathological HPASMC proliferation and migration during HPH progression. TRAF6 inhibition presents a potential therapeutic intervention against the pathological vascular remodeling in HPH.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) • XBP1 (X-box-binding protein 1) • ANXA5 (Annexin A5) • TRAF6 (TNF Receptor Associated Factor 6)
    2ms
    SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress. (PubMed, Nat Commun)
    Pharmacological inhibition of GADD34 using Sephin1 effectively suppressed XBP1 splicing and alleviated CAR-T cell exhaustion in an ex vivo model, leading to enhanced tumor-killing capacity across multiple cancer models. This work not only establishes a powerful new tool for systematically studying RNA splicing regulation but also uncovers a promising therapeutic strategy for improving CAR-T cell immunotherapy through modulation of the IRE1α-XBP1 pathway.
    Journal
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    PPP1R15A (Protein Phosphatase 1 Regulatory Subunit 15A) • XBP1 (X-box-binding protein 1)
    2ms
    RVd and CyBorD therapies remodel B-cell maturation signaling and alter immune and clonal architecture in multiple myeloma. (PubMed, Cancer Biol Ther)
    Although lenalidomide/bortezomib/dexamethasone (RVd) and cyclophosphamide/bortezomib/dexamethasone (CyBorD) are clinically effective, their precise impacts on PC/B-cell maturation remain unclear. RVd responders further downregulated CD56, CD269, and CD329, and increased CD243. These shared and divergent modulations elucidate the molecular underpinnings of RVd and CyBorD efficacy and inform precision regimen selection.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • FGFR3 (Fibroblast growth factor receptor 3) • NOTCH1 (Notch 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • TNFRSF17 (TNF Receptor Superfamily Member 17) • RARA (Retinoic Acid Receptor Alpha) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • PAX5 (Paired Box 5) • KLF4 (Kruppel-like factor 4) • NCAM1 (Neural cell adhesion molecule 1) • SDC1 (Syndecan 1) • CD200 (CD200 Molecule) • IRF4 (Interferon regulatory factor 4) • CD52 (CD52 Molecule) • PRDM1 (PR/SET Domain 1) • NANOG (Nanog Homeobox) • NES (Nestin) • XBP1 (X-box-binding protein 1) • CD81 (CD81 Molecule) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2) • SLAMF7 (SLAM Family Member 7) • SIGLEC9 (Sialic Acid Binding Ig Like Lectin 9)
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    lenalidomide • bortezomib • cyclophosphamide
    2ms
    Integrative bulk and single-cell transcriptomic profiling identifies core gene networks and potential therapeutic targets in glioma. (PubMed, BMC Cancer)
    The six identified hub genes are consistently downregulated in glioma and exhibit strong diagnostic potential. Their close association with the immune microenvironment and tumor-cell lineage highlights their value as biomarkers and potential therapeutic targets.
    Journal
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    SYP (Synaptophysin) • XBP1 (X-box-binding protein 1)