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    BIOMARKER:

    WSB1 expression

    i
    Other names: WSB1, WD Repeat And SOCS Box Containing 1, WD Repeat And SOCS Box-Containing Protein 1, SOCS Box-Containing WD Protein SWiP-1, SWIP1, WSB-1, WD Repeat And SOCS Box-Containing 1
    Entrez ID:
    26118
    2years
    circWSB1 promotes tumor progression in ccRCC via circWSB1/miR-182-5p/WSB1 axis. (PubMed, Int J Biol Macromol)
    circWSB1 diminishes the inhibitory impact of miR-182-5p on WSB1 and increases WSB1 expression, thereafter promoting ccRCC development. Our findings provide a promising predictive biomarker and therapeutic target for ccRCC.
    Journal
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    MIR182 (MicroRNA 182) • WSB1 (WD Repeat And SOCS Box Containing 1)
    |
    WSB1 expression
    over2years
    WSB1 Involvement in Prostate Cancer Progression. (PubMed, Genes (Basel))
    Our study is the first to show a link between WSB1 expression and other genes involved in PC progression, suggesting a novel role for WSB1 in PC progression. This network between WSB1 and EZH2 through WNT/β-catenin may have an important role in PC progression, as suggested by the association between high WSB1 expression and unfavorable prognosis in our analysis.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • WSB1 (WD Repeat And SOCS Box Containing 1)
    |
    MYC expression • WSB1 expression
    almost3years
    PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions. (PubMed, Cell Death Differ)
    The histological analyses show that PIN1 and CDK1 are highly expressed in TNBC samples, which negatively correlate with the expression of pVHL. Taken together, our findings reveal the previous unrecognized tumor-promoting function of CDK1/PIN1 axis through destabilizing pVHL and provide the preclinical evidence that targeting CDK1/PIN1 is an appealing strategy in the treatment of multiple cancers with wild-type VHL.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • CDK1 (Cyclin-dependent kinase 1) • WSB1 (WD Repeat And SOCS Box Containing 1)
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    WSB1 expression
    almost4years
    WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit. (PubMed, Acta Pharm Sin B)
    Moreover, overexpressing WSB1 in the Bel-7402 xenograft model could further strengthen the tumor-driven effect of c-Myc overexpression. Thus, our findings revealed a novel mechanism involved in tumorigenesis in which the WSB1/c-Myc feedforward circuit played an essential role, highlighting a potential c-Myc intervention strategy in cancer treatment.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • WSB1 (WD Repeat And SOCS Box Containing 1) • PPM1A (Protein Phosphatase Mg2+/Mn2+ Dependent 1A) • PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha 2)
    |
    MYC overexpression • MYC expression • WSB1 expression
    over5years
    High expression of WSB1 is associated with poor prognosis in hepatocellular carcinoma and affects epithelial-mesenchymal transition. (PubMed, J BUON)
    WSB1 might contribute into the development of HCC and serve as a clinical biomarker and a therapeutic target for HCC patients.
    Journal
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    CDH1 (Cadherin 1) • VIM (Vimentin) • WSB1 (WD Repeat And SOCS Box Containing 1)
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    CDH1 expression • VIM expression • WSB1 expression